Dkk1andWnt3interact to control head morphogenesis in the mouse
| العنوان: | Dkk1andWnt3interact to control head morphogenesis in the mouse |
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| المؤلفون: | Heiner Westphal, Robyn V. Jamieson, Lorraine Robb, Chris Wilcock, Mahua Mukhopadhyay, Poh-Lynn Khoo, Patrick P.L. Tam, Samara L. Lewis, Kirsten A. Steiner, R. Andrea De Young |
| المصدر: | Development. 135:1791-1801 |
| بيانات النشر: | The Company of Biologists, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | musculoskeletal diseases, Mutant, Morphogenesis, Down-Regulation, Germ layer, Biology, Wnt3 Protein, Mice, medicine, Animals, Molecular Biology, Body Patterning, Wnt signaling pathway, Gastrula, Mice, Mutant Strains, Cell biology, Wnt Proteins, Gastrulation, medicine.anatomical_structure, DKK1, Mutation, embryonic structures, Cancer research, Intercellular Signaling Peptides and Proteins, Head morphogenesis, Endoderm, Head, Signal Transduction, Developmental Biology |
| الوصف: | Loss of Dkk1 results in ectopic WNT/β-catenin signalling activity in the anterior germ layer tissues and impairs cell movement in the endoderm of the mouse gastrula. The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an antagonist-agonist interaction. The downregulation of Dkk1 when Wnt3 activity is reduced reveals a feedback mechanism for regulating WNT signalling. Compound Dkk1;Wnt3 heterozygous mutant embryos display head truncation and trunk malformation, which are not found in either Dkk1+/- or Wnt3+/- embryos. Reducing the dose of Wnt3 gene in Dkk1-/- embryos partially rescues the truncated head phenotype. These findings highlight that head development is sensitive to the level of WNT3 signalling and that DKK1 is the key antagonist that modulates WNT3 activity during anterior morphogenesis. |
| تدمد: | 1477-9129 0950-1991 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f63bdde4fee7ffc37ff7bcf6437706bTest https://doi.org/10.1242/dev.018853Test |
| رقم الانضمام: | edsair.doi.dedup.....6f63bdde4fee7ffc37ff7bcf6437706b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779129 09501991 |
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