Lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy improve the prediction of coronary artery disease in Type 1 diabetes. A prospective report from the Pittsburgh Epidemiology of Diabetes Complications Study
| العنوان: | Lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy improve the prediction of coronary artery disease in Type 1 diabetes. A prospective report from the Pittsburgh Epidemiology of Diabetes Complications Study |
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| المؤلفون: | S. S. Soedamah-Muthu, Jim Otvos, Trevor J. Orchard, Rhobert W. Evans, Y.-F. Chang |
| المصدر: | Diabetologia 46 (2003) 5 Diabetologia, 46(5), 674-682 |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Magnetic Resonance Spectroscopy, Nutrition and Disease, Heart disease, Endocrinology, Diabetes and Metabolism, cardiovascular-disease, Blood Pressure, Coronary Disease, Lipoproteins, VLDL, Coronary artery disease, chemistry.chemical_compound, Risk Factors, Voeding en Ziekte, Diabetic Nephropathies, Myocardial infarction, Registries, Age of Onset, risk-factors, plasma-lipoproteins, myocardial-infarction, Lipoproteins, LDL, Low-density lipoprotein, Cardiology, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, Adult, medicine.medical_specialty, Lipoproteins, men, vascular-disease, Predictive Value of Tests, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Triglycerides, VLAG, Type 1 diabetes, Analysis of Variance, low-density-lipoprotein, Vascular disease, Cholesterol, business.industry, Cholesterol, HDL, Cholesterol, LDL, medicine.disease, heart-disease, particle-size, Diabetes Mellitus, Type 1, chemistry, hepatic lipase activity, business, Diabetic Angiopathies |
| الوصف: | Aim/hypothesis. To examine whether nuclear magnetic resonance lipoprotein spectroscopy improves the prediction of coronary artery disease in patients with Type 1 diabetes, independently of conventional lipid and other risk factors. Methods. A prospective nested case-control design of subjects with childhood onset Type 1 diabetes from the Pittsburgh Epidemiology of Diabetes Complications Study was used. 59 controls were age-, sex- and duration-matched to 59 incident cases of coronary artery disease (fatal or non-fatal myocardial infarction, angina, coronary stenosis >50%) occurring during 10 years of follow-up. Lipid mass and particle concentrations of VLDL, LDL, and HDL subclasses, grouped into three size categories (large, medium, and small), were assessed prior to event with nuclear magnetic resonance spectroscopy. Results. Univariate analyses showed that both lipid mass and particle concentrations of all three VLDL subclasses, small LDL, medium LDL, and medium HDL were increased in CAD cases compared to controls, while large HDL was decreased. Mean LDL and HDL particle sizes were lower in cases. In multivariate models using conventional lipid and non-lipid risk factors, triglycerides and overt nephropathy were the strongest predictors of CAD. Nuclear magnetic resonance measures further improved the prediction, i.e. large HDL particle concentration (OR=0.43, p=0.030), medium HDL mass (OR=3.79, p=0.026) and total VLDL particle concentration (OR=2.33, p=0.033). Conclusion/interpretation. While these results underscore the importance of triglycerides and overt nephropathy in CAD risk in Type 1 diabetic patients, they also suggest that nuclear magnetic resonance lipoprotein spectroscopy could further refine its prediction and show novel findings concerning HDL subclasses |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f559799663c3a7a62a959e00a0dda75Test https://pubmed.ncbi.nlm.nih.gov/12743701Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6f559799663c3a7a62a959e00a0dda75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0012186X |
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