Effect of Intravenous Infusion of a 7.2% Hypertonic Saline Solution on Serum Electrolytes and Osmotic Pressure in Healthy Beagles
| العنوان: | Effect of Intravenous Infusion of a 7.2% Hypertonic Saline Solution on Serum Electrolytes and Osmotic Pressure in Healthy Beagles |
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| المؤلفون: | Shigehiro Iwabuchi, Tadaharu Ajito, Kazuyuki Suzuki |
| المصدر: | Journal of Veterinary Medical Science. 61:637-641 |
| بيانات النشر: | Japanese Society of Veterinary Science, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, Resuscitation, Sodium, chemistry.chemical_element, Blood Pressure, Plasma volume, Dogs, Osmotic Pressure, medicine, Animals, Osmotic pressure, Plasma Volume, Infusions, Intravenous, Saline Solution, Hypertonic, integumentary system, General Veterinary, Hypertonic Saline Solution, medicine.disease, Blood pressure, chemistry, Anesthesia, Potassium, Serum electrolytes, Female, Hypernatremia |
| الوصف: | The effect of an intravenous (i.v.) infusion of hypertonic saline solution (HSS; 7.2%, 2,400 mOsmol/kg.H2O) was evaluated by serum electrolyte concentrations and osmotic pressure in the anesthetized beagles. Sixteen beagles were assigned to 3 experimental groups (2.5, 5 or 15 ml/kg of HSS i.v. infusion) or a control group (5 ml/kg of isotonic saline solution (ISS) i.v. infusion) and were monitored for 120 min after the initiation of fluid infusion. The relative plasma volume (rPV) in the 5 ml/kg and 15 ml/kg HSS groups progressively expanded to 143.1 +/- 7.4% at 3 min and 156.4 +/- 5.9% at 5 min after the initiation of the fluid infusion, respectively. Significant increases were not produced by ISS and 2.5 ml/kg HSS infusion. The serum sodium and chloride concentrations in the ISS group were not altered. The 5 ml/kg HSS infusion induced transient high osmotic and sodium levels, and the serum sodium concentration remained under the 160 mM/l after the completion of the HSS infusion. However, the 15 ml/kg HSS infusion induced a constant high osmotic level (340.5-352.8 mOsmol/kg.H2O) and hypernatremia (161.4-174.5 mM/l) from 10 to 90 min after the initiation of the fluid infusion. The 15 ml/kg HSS infusion induced significant decreases in the partial pressure of oxygen (PaO2), reaching 63.7 +/- 8.0 mmHg at 120 min after the initiation of the fluid infusion compared with an immediately before fluid infusion value. On the basis of these findings, 5 ml/kg HSS infusion can be safely administered to healthy beagles for expanding the plasma volume without inducing hypernatremia. A 5 ml/kg HSS infusion is thus recommended for the initial field resuscitation of dogs. |
| تدمد: | 1347-7439 0916-7250 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10e20f18f0a0c3436cb7ee286b9988Test https://doi.org/10.1292/jvms.61.637Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6f10e20f18f0a0c3436cb7ee286b9988 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13477439 09167250 |
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