Frequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth‐onset type 2 diabetes: Results from a nationwide, multicentre, clinic‐based, cross‐sectional study (LADA China)
| العنوان: | Frequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth‐onset type 2 diabetes: Results from a nationwide, multicentre, clinic‐based, cross‐sectional study (LADA China) |
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| المؤلفون: | Shuoming Luo, Zhiguang Zhou, Jian Lin, Aimin Xu, Xiaojue Li, Zhihong Che, Bingwen Liu, Yufei Xiang, Gan Huang, Pengcheng Zhou, Zhiguo Xie, Lin Yang, Chuan Yun, Xia Li |
| المصدر: | Diabetes, Obesity and Metabolism. 23:1282-1291 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, China, medicine.medical_specialty, Adolescent, Cross-sectional study, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Autoantibodies, Type 1 diabetes, Adiponectin, business.industry, Autoantibody, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Cytokines, Metabolic syndrome, business, Genetic Background, Body mass index |
| الوصف: | AIM To investigate the frequency, clinical phenotype, inflammatory cytokine levels and genetics of glutamic acid decarboxylase autoantibody (GADA)-positive phenotypic youth-onset type 2 diabetes. MATERIALS AND METHODS This nationwide, multicentre, cross-sectional study included 5324 newly diagnosed subjects with phenotypic type 2 diabetes aged 15 years or older enrolled in the LADA China study. GADA was screened in 248 subjects with youth-onset type 2 diabetes aged 15-29 years. Subjects who presented as GADA-positive were defined as having latent autoimmune diabetes in youth (LADY). We added subjects with LADY, type 1 diabetes, type 2 diabetes and controls from the Diabetes Center of Central South University, and measured serum concentrations of interleukin-6, lipocalin 2, high-sensitivity C-reactive protein, adiponectin and human leukocyte antigen (HLA) genotyping in subjects with LADY, age- and sex-matched GADA-negative type 2 diabetes, type 1 diabetes and controls. RESULTS Twenty-nine of the 248 subjects (11.7%) were GADA positive. Compared with subjects with type 2 diabetes, subjects with LADY were less probable to have metabolic syndrome (27.6% vs. 59.4%; p = .001). The fasting C-peptide levels tended to be lower in subjects with LADY than in subjects with type 2 diabetes, but the difference was not statistically significant (LADY vs. type 2 diabetes: 0.21 [0.17-0.64] vs. 0.47 [0.29-0.77] nmol/L; p = .11). The cytokine levels of subjects with LADY were indistinguishable from subjects with type 1 diabetes, but subjects with LADY presented increased adiponectin levels compared with subjects with type 2 diabetes after adjusting for age, sex and body mass index (7.19 [4.05-11.66] vs. 3.42 [2.35-5.74] μg/mL; p |
| تدمد: | 1463-1326 1462-8902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3be3078c5fc95d97c886579978b106Test https://doi.org/10.1111/dom.14336Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6e3be3078c5fc95d97c886579978b106 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14631326 14628902 |
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