Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects
| العنوان: | Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects |
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| المؤلفون: | Peter J. Joris, Lotte Smolders, Jogchum Plat, Jose J. van den Driessche, Ronald P. Mensink |
| المساهمون: | RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Promovendi NTM, Nutrition and Movement Sciences |
| المصدر: | European Journal of Nutrition European Journal of Nutrition, 58(3), 981-987. Springer |
| بيانات النشر: | Springer, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Vasodilator Agents, Medicine (miscellaneous), Blood Pressure, BLOOD-PRESSURE, 0302 clinical medicine, HDL-CHOLESTEROL, Microvasculature, Brachial artery, Pulse wave velocity, Cross-Over Studies, Nutrition and Dietetics, CARDIOVASCULAR HEALTH, Postprandial, FLOW-MEDIATED DILATION, Fasting, Original Contribution, Middle Aged, Postprandial Period, Arterial stiffness, 3. Good health, Cardiology, DEPENDENT VASODILATION, Theobromine, Female, medicine.drug, medicine.medical_specialty, ENDOTHELIAL FUNCTION, 030209 endocrinology & metabolism, DARK CHOCOLATE, Pulse Wave Analysis, 03 medical and health sciences, Double-Blind Method, medicine.artery, Internal medicine, BRACHIAL-ARTERY, medicine, Humans, Obesity, Reactive hyperemia, Aged, 030109 nutrition & dietetics, business.industry, Retinal Vessels, Overweight, medicine.disease, Crossover study, Blood pressure, Microvessels, Endothelium, Vascular, CHOCOLATE CONSUMPTION, business |
| الوصف: | Backgound Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. Objective To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers. Design In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks. After 4 weeks, FMD, peripheral arterial tonometry (PAT), augmentation index (AIx), pulse wave velocity (PWV), blood pressure (BP) and retinal microvasculature measurements were performed. These measurements were carried out under fasting conditions and 2.5 h after a high-fat mixed meal challenge. Results 4-week theobromine consumption did not change fasting vascular function markers, except for a decrease in central AIx (cAIx, − 1.7 pp, P = 0.037) and a trend towards smaller venular calibers (− 2 µm, P = 0.074). Consuming a high-fat mixed meal decreased FMD (0.89 pp, P = 0.002), reactive hyperemia index (RHI, − 0.30, P |
| اللغة: | English |
| تدمد: | 1436-6215 1436-6207 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de5fb22801c04812a79a50e0b9151a2Test https://doi.org/10.1007/s00394-018-1612-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6de5fb22801c04812a79a50e0b9151a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14366215 14366207 |
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