Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response
| العنوان: | Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response |
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| المؤلفون: | Hana Šváchová, Pavel Nemec, L. Kovarova, Zdenek Adam, Miroslav Penka, Ludek Pour, Lucie Burešová, Martina Almáši, Roman Hájek, Tomas Buchler, Jiri Vorlicek |
| المساهمون: | Departement of Internal Medicine-Hematooncology, University Hospital Brno, Czech Myeloma Group, University Research Centre, Institute of Biostatistics and Analyses [Brno] (IBA MED / MUNI), Faculty of Medicine [Brno] (MED / MUNI), Masaryk University [Brno] (MUNI)-Masaryk University [Brno] (MUNI), Departement of Oncology, 1st Faculty of Medicine and Thomayer University Hospital, Departement of Clinical Hematology |
| المصدر: | Annals of Hematology Annals of Hematology, Springer Verlag, 2009, 89 (4), pp.385-389. ⟨10.1007/s00277-009-0834-3⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Therapeutic response, Angiogenesis, Basic fibroblast growth factor, Antineoplastic Agents, Thrombospondin 1, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, High-dose chemotherapy, medicine, Humans, Angiostatins, Aged, 030304 developmental biology, 0303 health sciences, Angiostatin, Hepatocyte Growth Factor, business.industry, Hematology, General Medicine, Middle Aged, 3. Good health, Vascular endothelial growth factor, Vascular endothelial growth factor A, Treatment Outcome, medicine.anatomical_structure, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Cytokines, Female, Hepatocyte growth factor, Bone marrow, Endostatin, Multiple Myeloma, business, medicine.drug |
| الوصف: | International audience; Angiogenesis plays a significant role in the pathogenesis of multiple myeloma (MM). We have measured concentrations of angiogenesis activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hepatocyte growth factor (HGF), and inhibitors, including endostatin, thrombospondin-1 (TSP-1), and angiostatin in the peripheral and bone marrow blood of MM patients at diagnosis and after high-dose chemotherapy. We have analyzed 96 patients with secretory MM. Serial measurements of angiogenesis factors/inhibitors were analyzed in the plasma by subgroups based on the best treatment response. Concentrations of angiogenic factors were determined in the peripheral blood and bone marrow plasma. There were significant decreases of VEGF and HGF levels and a significant increase in TSP-1 concentrations in the bone marrow plasma of patients who achieved complete or very good partial response in contrast to those who had partial or no response. VEGF and HGF levels decrease but those of TSP-1 increase after successful treatment for MM, indicating a reduction in the rate of angiogenesis. |
| تدمد: | 1432-0584 0939-5555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcb8937e6a0978c97664bbcd161e80eTest https://doi.org/10.1007/s00277-009-0834-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6dcb8937e6a0978c97664bbcd161e80e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320584 09395555 |
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