Supplementary Figures 1 - 3 from Regression of Metastatic Merkel Cell Carcinoma Following Transfer of Polyomavirus-Specific T Cells and Therapies Capable of Reinducing HLA Class-I
التفاصيل البيبلوغرافية
العنوان:
Supplementary Figures 1 - 3 from Regression of Metastatic Merkel Cell Carcinoma Following Transfer of Polyomavirus-Specific T Cells and Therapies Capable of Reinducing HLA Class-I
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
PDF file - 738K, Supplementary Fig. S1: Detection of MCPyV-specific CD8 T cells among tumor infiltrating lymphocytes (TIL) from the primary MCC tumor (left) and PBMC (right). Cells were stained with A24/MCPyV.LT.92-101 tetramer and CD8. Supplementary Fig. S2: A) Cell products destined for infusions 1, 2 and 3 bound the MCPyV LT-Ag92-101 peptide-HLA tetramer. B) Products secreted IFNγ (left) and lysed MCPyV LT-Ag92-101 -pulsed FUJI (A24+ cell line) and autologous PBMC pulsed with 10?g/ml peptide (right). The product used for infusion 1 is shown and is representative. Supplementary Fig. S3: Assessment of CD25hiCD127loCD4+ T-cells in PBMC collected at baseline (137 days and immediately prior to the first treatment) and at indicated timepoints after treatments. Gray bars on x-axis indicate the timing of each treatment as detailed in Figure 1.
