Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load
| العنوان: | Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load |
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| المؤلفون: | Fabio E. Leal, Sabri Saeed Sanabani, Ester Cerdeira Sabino, Youko Nukui, Antonio Charlys da Costa, Rodrigo Pessôa, Ana Carolina Soares de Oliveira, Juliana Pereira, Esper G. Kallas, Aluísio Augusto Cotrim Segurado |
| المصدر: | BMC Infectious Diseases, Vol 12, Iss 1, p 374 (2012) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Genotype, Proviral load, T-cell leukemia, Biology, Polymorphism, Single Nucleotide, lcsh:Infectious and parasitic diseases, Young Adult, immune system diseases, hemic and lymphatic diseases, Tropical spastic paraparesis, medicine, Humans, lcsh:RC109-216, Aged, Human T-lymphotropic virus 1, Interleukins, virus diseases, Middle Aged, Viral Load, medicine.disease, biology.organism_classification, HTLV-I Infections, Leukemia, Infectious Diseases, Interleukin 28B, HTLV-1, Immunology, Female, Interferons, ILB 28 polymorphisms, HAM/TSP, Asymptomatic carrier, Viral load, Research Article |
| الوصف: | Background The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population. |
| اللغة: | English |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d94f891a179916e3887efa3e22898b6Test http://www.biomedcentral.com/1471-2334/12/374Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d94f891a179916e3887efa3e22898b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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