Semantic integration of data on transcriptional regulation
| العنوان: | Semantic integration of data on transcriptional regulation |
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| المؤلفون: | Michael Baitaluk, Julia Ponomarenko |
| المصدر: | Bioinformatics. 26:1651-1661 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Statistics and Probability, Transcription, Genetic, Computer science, Gene regulatory network, Genomics, computer.software_genre, Biochemistry, Annotation, Text mining, Gene Regulatory Networks, Semantic integration, Molecular Biology, business.industry, Ontology-based data integration, Computational Biology, Original Papers, Data science, Computer Science Applications, Data mapping, Computational Mathematics, ComputingMethodologies_PATTERNRECOGNITION, Gene Expression Regulation, Computational Theory and Mathematics, Graph (abstract data type), ComputingMethodologies_GENERAL, Data mining, business, computer, Data integration |
| الوصف: | Motivation: Experimental and predicted data concerning gene transcriptional regulation are distributed among many heterogeneous sources. However, there are no resources to integrate these data automatically or to provide a ‘one-stop shop’ experience for users seeking information essential for deciphering and modeling gene regulatory networks. Results: IntegromeDB, a semantic graph-based ‘deep-web’ data integration system that automatically captures, integrates and manages publicly available data concerning transcriptional regulation, as well as other relevant biological information, is proposed in this article. The problems associated with data integration are addressed by ontology-driven data mapping, multiple data annotation and heterogeneous data querying, also enabling integration of the user's data. IntegromeDB integrates over 100 experimental and computational data sources relating to genomics, transcriptomics, genetics, and functional and interaction data concerning gene transcriptional regulation in eukaryotes and prokaryotes. Availability: IntegromeDB is accessible through the integrated research environment BiologicalNetworks at http://www.BiologicalNetworks.orgTest Contact: baitaluk@sdsc.edu Supplementary information: Supplementary data are available at Bioinformatics online. |
| تدمد: | 1367-4811 1367-4803 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6807cd0827b1b3e64a43808f9131e3Test https://doi.org/10.1093/bioinformatics/btq231Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d6807cd0827b1b3e64a43808f9131e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13674811 13674803 |
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