Cortico-Brainstem Mechanisms of Biased Perceptual Decision-Making in the Context of Pain
| العنوان: | Cortico-Brainstem Mechanisms of Biased Perceptual Decision-Making in the Context of Pain |
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| المؤلفون: | Jonas Zaman, Irene Tracey, Joachim Vandekerckhove, Francis Tuerlinckx, Katerina Placek, Johan W.S. Vlaeyen, Katja Wiech, Falk Eippert |
| المساهمون: | Section Experimental Health Psychology, RS: FPN CPS I |
| المصدر: | bioXriv The Journal of Pain, 23(4), 680-692. Churchill Livingstone The Journal of Pain |
| بيانات النشر: | Churchill Livingstone, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | bias, PREDICTION, media_common.quotation_subject, DORSOLATERAL PREFRONTAL CORTEX, Pain, Context (language use), Stimulus (physiology), FEAR, Amygdala, Periaqueductal gray, Midbrain, 03 medical and health sciences, 0302 clinical medicine, CONNECTIVITY, Perception, Noxious stimulus, Medicine, Humans, MODULATION, prefrontal, Sensory cue, HUMAN PARIETAL OPERCULUM, media_common, 030304 developmental biology, Pain Measurement, 0303 health sciences, medicine.diagnostic_test, PLACEBO, business.industry, amygdala, Magnetic Resonance Imaging, Dorsolateral prefrontal cortex, Perceptual decision-making, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Neurology, nervous system, EXPECTATION, FMRI, periaqueductal gray, Brainstem, Neurology (clinical), Cues, Psychology, business, Functional magnetic resonance imaging, Neuroscience, 030217 neurology & neurosurgery, Brain Stem |
| الوصف: | Prior expectations can bias how we perceive pain. Using a drift diffusion model, we recently showed that this influence is primarily based on changes in perceptual decision-making (indexed as shift in starting point). Only during unexpected application of high-intensity noxious stimuli, altered information processing (indexed as increase in drift rate) explained the expectancy effect on pain processing. Here, we employed functional magnetic resonance imaging to investigate the neural basis of both these processes in healthy volunteers. On each trial, visual cues induced the expectation of high- or low-intensity noxious stimulation or signaled equal probability for both intensities. Participants categorized a subsequently applied electrical stimulus as either low- or high-intensity pain. A shift in starting point towards high pain correlated negatively with right dorsolateral prefrontal cortex activity during cue presentation underscoring its proposed role of "keeping pain out of mind". This anticipatory right dorsolateral prefrontal cortex signal increase was positively correlated with periaqueductal gray (PAG) activity when the expected high-intensity stimulation was applied. A drift rate increase during unexpected high-intensity pain was reflected in amygdala engagement and increased functional connectivity between amygdala and PAG. Our findings suggest involvement of the PAG in both decision-making bias and altered information processing to implement expectancy effects on pain. PERSPECTIVE: Modulation of pain through expectations has been linked to changes in perceptual decision-making and altered processing of afferent information. Our results suggest involvement of the dorsolateral prefrontal cortex, amygdala, and periaqueductal gray in these processes. |
| وصف الملف: | application/pdf; Print-Electronic |
| اللغة: | English |
| تدمد: | 1528-8447 1526-5900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfb9fa42038dbe58d24ac44d622ea0dTest https://doi.org/10.1016/j.jpain.2021.11.006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6cfb9fa42038dbe58d24ac44d622ea0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15288447 15265900 |
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