Modification of the erythrocyte anion carrier by chromate
| العنوان: | Modification of the erythrocyte anion carrier by chromate |
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| المؤلفون: | D Beyersmann, B Buttner |
| المصدر: | Xenobiotica. 15:735-741 |
| بيانات النشر: | Informa UK Limited, 1985. |
| سنة النشر: | 1985 |
| مصطلحات موضوعية: | Pharmacology, Prolonged incubation, Erythrocytes, Chromate conversion coating, Sulfates, Health, Toxicology and Mutagenesis, Anion Transport Proteins, Kinetics, Inorganic chemistry, chemistry.chemical_element, Biological Transport, General Medicine, Sulfur Radioisotopes, Toxicology, Biochemistry, Ion, Chromium, chemistry, Chromates, Humans, Human erythrocytes, Carrier Proteins, Intracellular, Nuclear chemistry |
| الوصف: | It was confirmed that chromate is taken up by human erythrocytes via the general anion carrier. The chromate flux is unidirectional and chromium is accumulated within red cells presumably due to intracellular reduction of Cr(VI) to Cr(III). The analysis of the initial rates of uptake of chromate revealed two distinct uptake mechanisms at low (0.001-0.01 mM) and at high (0.05-1.0 mM) chromate concentrations. After prolonged incubation with 1 mM chromate, the subsequent rate of uptake of chromate was decreased. It is suggested that the decreased uptake is due to a modification of the anion-transport protein by chromate. |
| تدمد: | 1366-5928 0049-8254 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c599ef138a46edfd630244815b8f9e2Test https://doi.org/10.3109/00498258509047435Test |
| رقم الانضمام: | edsair.doi.dedup.....6c599ef138a46edfd630244815b8f9e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13665928 00498254 |
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