Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes
| العنوان: | Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes |
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| المؤلفون: | D. Matheson, Xiaodong Cai, J. S. Skyler, J. Wen, Dongmei Han, Z. Chen, Norma S. Kenyon |
| المصدر: | Clinical and Experimental Immunology. 170:131-138 |
| بيانات النشر: | Oxford University Press (OUP), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Myeloid, Adolescent, T-Lymphocytes, Lymphocyte, Immunology, Adaptive Immunity, Biology, Young Adult, Immune system, Antigen, Antigens, CD, Immunity, medicine, Humans, Immunology and Allergy, Cytotoxic T cell, CTLA-4 Antigen, RNA, Messenger, Regulator gene, Innate immune system, Arginase, Gene Expression Profiling, S100 Proteins, Original Articles, Middle Aged, Immunity, Innate, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Gene Expression Regulation, Toll-Like Receptor 9, Female, Biomarkers |
| الوصف: | Summary The mRNA levels of a set of immune-related genes were analysed with peripheral blood samples from at-risk, new-onset and long-term type 1 diabetes (T1D) patients, in comparison to those from healthy controls. The selected set includes T lymphocyte genes [CD3G and cytotoxic T lymphocyte-associated antigen 4 (CTLA4)], B lymphocyte genes (CD19 and CD20) and myeloid cell-related genes [CD11b, Toll-like receptor (TLR)-9, arginase (ARG1)]. Also included is a subset of the S100 family members that has been documented recently as regulatory elements of innate immunity. Samples from patients with long-term T1D had a reduced level of mRNA for most of selected innate and adaptive immune genes. No such reduction was detected in samples collected from at-risk or new-onset T1D patients. Analyses of regulatory gene expression ratios revealed a dynamic disproportion of CTLA4 versus CD3G expression in samples from at-risk, new-onset and long-term T1D patients. These changes could serve as immunological biomarkers for the status of the immune system during T1D progression and therapeutic interventions. |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1bc1956c868ccadff1cb31628a46a7Test https://doi.org/10.1111/j.1365-2249.2012.04650.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6c1bc1956c868ccadff1cb31628a46a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
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