Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data
| العنوان: | Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
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| المؤلفون: | Megan K. Horton, Susan F. Tapert, Joanna Jacobus, Wesley K. Thompson, Charles J. Heyser, Elizabeth R. Sowell, Kristina A. Uban, Pamela A. F. Madden |
| المصدر: | Developmental cognitive neuroscience Developmental Cognitive Neuroscience, Vol 32, Iss, Pp 97-106 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Drugs of abuse, Future studies, Recreational Drug, Adolescent, Gonadal hormones, Cognitive Neuroscience, Biospecimens, Neuroimaging, Substance use, Biospecimen Collection, Article, Specimen Handling, Child and adolescent, 03 medical and health sciences, 0302 clinical medicine, Cognition, Cognitive development, Genetics, Humans, Child, lcsh:QP351-495, Environmental exposures, Brain, Adolescent Development, Cognitive test, lcsh:Neurophysiology and neuropsychology, 030104 developmental biology, ABCD study, Female, Psychology, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study – of hair samples, shed deciduous (baby) teeth, and body fluids – will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations. Keywords: Biospecimens, ABCD study, Substance use, Gonadal hormones, Genetics, Environmental exposures |
| اللغة: | English |
| تدمد: | 1878-9307 1878-9293 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf8ba60aa573f86eb8ef79a1ed7278dTest http://europepmc.org/articles/PMC6487488Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6bf8ba60aa573f86eb8ef79a1ed7278d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18789307 18789293 |
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