OBJECTIVES: Inflammatory processes play an important role in the initiation and progression of kidney disease. Renal calcium oxalate stone formed from the crystal deposits in the tubular epithelial cells can increase reactive oxygen species and subsequent inflammation. We investigated the gene expression METHODS: At the time of death the circulating levels of creatinine and SDMA, markers of kidney decline, were significantly higher in cats with renal disease (n = 11) or stone-forming cats (CaOx, n = 12) when compared to controls (n = 19). RESULTS: We identified 3 candidate genes including complement C3d receptor (CR2), MMP-7, and IKAROS family zinc finger 3, that were maximally up-regulated in renal disease with fold increases of 14.3, 13.9, and 10.9 when compared to controls (p
