Basic biochemical and hematological parameters in perinatal asphyxia and their correlation with hypoxic ischemic encephalopathy
| العنوان: | Basic biochemical and hematological parameters in perinatal asphyxia and their correlation with hypoxic ischemic encephalopathy |
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| المؤلفون: | Andrei Ioan Munteanu, Cristian Jinca, Aniko-Maria Manea, Marioara Boia |
| المصدر: | Exp Ther Med |
| بيانات النشر: | Spandidos Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, Encephalopathy, Brain damage, Gastroenterology, Hypoxic Ischemic Encephalopathy, Procalcitonin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immunology and Microbiology (miscellaneous), Internal medicine, Lactate dehydrogenase, medicine, Asphyxia, business.industry, Articles, General Medicine, Hypoxia (medical), medicine.disease, Perinatal asphyxia, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, medicine.symptom, business |
| الوصف: | Perinatal hypoxic-ischemic encephalopathy (HIE) represents a major cause of neonatal death or long-term disability. Inflammation plays an important role in mediating brain damage induced by neonatal hypoxic-ischemic encephalopathy. The mechanisms underlying the inflammatory response in hypoxia and ischemia are complex and are still being extensively researched. The objective of this study was to determine the predictive value of peak lactate dehydrogenase (LDH), C-reactive protein (CRP), procalcitonin (PCT) and of the evolution of leukocytes, neutrophils and lymphocytes in the first 96 h after birth for the grade of encephalopathy and neurodevelopmental outcome in newborns with HIE. In order to reveal this relationship we used comparisons between the above mention parameters. The observed hematological changes were nonspecific. The vast majority of the 78 newborns included in the study had PCT values above normal in the first 24 h, contrasting with CRP values that were positive in only 15.8% of the patients. A total of 76.9% of the patients had LDH values higher than the upper limit of normal values. The mean LDH values in patients with an unfavorable prognosis were 1,235 U/l. We can conclude that LDH is a good predictor of HIE in the first 12/24 h after birth. |
| تدمد: | 1792-1015 1792-0981 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9aca34fde040b612978dddcd7b8ff0Test https://doi.org/10.3892/etm.2021.9690Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b9aca34fde040b612978dddcd7b8ff0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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