Relative Effectiveness of the Cell-derived Inactivated Quadrivalent Influenza Vaccine Versus Egg-derived Inactivated Quadrivalent Influenza Vaccines in Preventing Influenza-related Medical Encounters During the 2018–2019 Influenza Season in the United States
| العنوان: | Relative Effectiveness of the Cell-derived Inactivated Quadrivalent Influenza Vaccine Versus Egg-derived Inactivated Quadrivalent Influenza Vaccines in Preventing Influenza-related Medical Encounters During the 2018–2019 Influenza Season in the United States |
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| المؤلفون: | James A. Mansi, Constantina Boikos, Lauren Fischer, Joseph Vasey, Gregg C Sylvester, Daniel P O'Brien |
| المصدر: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Quadrivalent Inactivated Influenza Vaccine, medicine.medical_specialty, Adolescent, egg-derived influenza vaccine, quadrivalent inactivated influenza vaccine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Influenza, Human, medicine, Humans, 030212 general & internal medicine, Vaccines, Combined, Online Only Articles, Child, Retrospective Studies, business.industry, Public health, Medical record, cell-derived influenza vaccine, relative vaccine effectiveness, Retrospective cohort study, Odds ratio, Confidence interval, United States, Vaccination, Major Articles and Commentaries, 030104 developmental biology, Infectious Diseases, AcademicSubjects/MED00290, Vaccines, Inactivated, Influenza Vaccines, Child, Preschool, Cohort, Seasons, business, influenza |
| الوصف: | Background The cell-propagated inactivated quadrivalent influenza vaccine (ccIIV4) may offer improved protection in seasons where egg-derived influenza viruses undergo mutations that affect antigenicity. This study estimated the relative vaccine effectiveness (rVE) of ccIIV4 versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018–2019 US season. Methods A dataset linking primary care electronic medical records with medical claims data was used to conduct a retrospective cohort study among individuals ≥ 4 years old vaccinated with ccIIV4 or eIIV4 during the 2018–2019 season. Adjusted odds ratios (ORs) were derived from a doubly robust inverse probability of treatment-weighted approach adjusting for age, sex, race, ethnicity, geographic region, vaccination week, and health status. rVE was estimated by (1 – OR) × 100 and presented with 95% confidence intervals (CI). Results Following the application of inclusion/exclusion criteria, the study cohort included 2 125 430 ccIIV4 and 8 000 903 eIIV4 recipients. Adjusted analyses demonstrated a greater reduction in influenza-related medical encounters with ccIIV4 versus eIIV4, with the following rVE: overall, 7.6% (95% CI, 6.5–8.6); age 4–17 years, 3.9% (95% CI, .9–7.0); 18–64 years, 6.5% (95% CI, 5.2–7.9); 18–49 years, 7.5% (95% CI, 5.7–9.3); 50–64 years, 5.6% (95% CI, 3.6–7.6); and ≥65 years, –2.2% (95% CI, –5.4 to .9). Conclusions Adjusted analyses demonstrated statistically significantly greater reduction in influenza-related medical encounters in individuals vaccinated with ccIIV4 versus eIIV4 in the 2018–2019 US influenza season. These results support ccIIV4 as a potentially more effective public health measure against influenza than an egg-based equivalent. During the 2018–2019 influenza season in the U.S., the cell-derived quadrivalent influenza vaccine demonstrated statistically significantly greater effectiveness in reducing influenza-related medical encounters in individuals ≥4 years of age compared to egg-derived quadrivalent vaccines. |
| اللغة: | English |
| تدمد: | 1537-6591 1058-4838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2196d66cf8fd5eb2d731b581330378Test http://europepmc.org/articles/PMC8326580Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b2196d66cf8fd5eb2d731b581330378 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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