GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle
| العنوان: | GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle |
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| المؤلفون: | Erik A. Richter, Bente Kiens, Stephen Rattigan, Kim A. Sjøberg, Jens J. Holst |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 306:E355-E362 |
| بيانات النشر: | American Physiological Society, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Physiology, Vastus lateralis muscle, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucose uptake, Femoral artery, Biology, Octreotide, Rats, Sprague-Dawley, Gastrointestinal Agents, Glucagon-Like Peptide 1, Physiology (medical), Internal medicine, medicine.artery, medicine, Animals, Humans, Muscle, Skeletal, Ultrasonography, Leg, Gastrointestinal agent, Insulin, digestive, oral, and skin physiology, Skeletal muscle, Articles, Glucose clamp technique, Glucagon-like peptide-1, Capillaries, Rats, Femoral Artery, Glucose, Endocrinology, medicine.anatomical_structure, Glucose Clamp Technique |
| الوصف: | The insulinotropic gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight-fasted, healthy young men. Microvascular recruitment was measured with real-time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by coinfusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic-euglycemic clamp. Infusion of GLP-1 caused a rapid increase ( P < 0.05) of 20 ± 12% (mean ± SE) in MVR in the vastus lateralis muscle of the infused leg after 5 min, and MVR further increased to 60 ± 8% above preinfusion levels by 60 min infusion. The effect was slightly slower but similar in magnitude in the noninfused contralateral leg, in which GLP-1 concentration was within the physiological range. Octreotide infusion did not prevent the GLP-1-induced increase in MVR. GLP-1 infusion did not increase leg glucose uptake with or without octreotide coinfusion. GLP-1 infusion in rats increased MVR by 28% ( P < 0.05) but did not increase muscle glucose uptake. During the hyperinsulinemic clamp, MVR increased ∼40%, and leg glucose uptake increased 35-fold. It is concluded that GLP-1 in physiological concentrations causes a rapid insulin-independent increase in muscle MVR but does not affect muscle glucose uptake. |
| تدمد: | 1522-1555 0193-1849 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f6fdb615079a92ae1b1ad0586986f0Test https://doi.org/10.1152/ajpendo.00283.2013Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....69f6fdb615079a92ae1b1ad0586986f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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