Triglyceride Glucose Index and Common Carotid Wall Shear Stress
| العنوان: | Triglyceride Glucose Index and Common Carotid Wall Shear Stress |
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| المؤلفون: | Faustina Scavelli, Maria Serena De Franceschi, Cesare Tripolino, Teresa Esposito, Concetta Irace, Claudio Carallo, Agostino Gnasso |
| المصدر: | Journal of Investigative Medicine. 62:340-344 |
| بيانات النشر: | SAGE Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Carotid Artery, Common, Carotid arteries, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Insulin resistance, medicine.artery, Internal medicine, Diabetes mellitus, Shear stress, Humans, Medicine, Common carotid artery, Triglycerides, Aged, Ultrasonography, Triglyceride, business.industry, General Medicine, Middle Aged, medicine.disease, Obesity, Endocrinology, Blood pressure, chemistry, Female, Stress, Mechanical, Insulin Resistance, Shear Strength, business |
| الوصف: | Objectives Alterations in wall shear stress contribute to both clinical and subclinical atherosclerosis. Several conditions such as hypertension, diabetes, and obesity can impair shear stress, but the role of insulin resistance has never been investigated. The present study was designed to investigate whether insulin resistance assessed by TyG Index associates with wall shear stress in the common carotid artery. Methods One hundred six individuals were enrolled. Blood pressure, lipids, glucose, and cigarette smoking were evaluated. TyG Index was calculated as log[fasting triglycerides × fasting glucose / 2]. Subjects underwent blood viscosity measurement and echo-Doppler evaluation of carotid arteries to calculate wall shear stress. The association between TyG Index and carotid wall shear stress was assessed by simple and multiple regression analyses. Results TyG Index was significantly and inversely associated with carotid wall shear stress both in simple ( r = −0.44, P < 0.001) and multiple regression analyses accounting for age, sex, and major cardiovascular risk factors. The association was further confirmed after exclusion of subjects with diabetes, dyslipidemia, fasting blood glucose greater than 100 mg/dL, and triglycerides greater than 150 mg/dL. Conclusions The present findings suggest that increasing insulin resistance, as assessed by TyG Index, associates with atherosclerosis-prone shear stress reduction in the common carotid artery. |
| تدمد: | 1708-8267 1081-5589 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c847da1d536253f49443fb34f11590Test https://doi.org/10.2310/jim.0000000000000043Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....68c847da1d536253f49443fb34f11590 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17088267 10815589 |
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