The Role of NLRP3 Inflammasome in Pericarditis
| العنوان: | The Role of NLRP3 Inflammasome in Pericarditis |
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| المؤلفون: | Nicola Potere, Aldo Bonaventura, Antonio Abbate, Alessandra Vecchié, Salvatore Carbone, Gianfranco Sinagra, Fabrizio Montecucco, Eleonora Mezzaroma, Antonio Cannatà, Rossana Bussani, John F. Paolini, Stefano Toldo, Pratyush Narayan, Benjamin W. Van Tassel, Adolfo G Mauro |
| المصدر: | JACC: Basic to Translational Science |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Inflammation, 030204 cardiovascular system & hematology, pericarditis, NLRP3inh, NLRP3 inflammasome inhibitor, colchicine, 03 medical and health sciences, chemistry.chemical_compound, Pericarditis, 0302 clinical medicine, Colchicine, Medicine, Pathological, Anakinra, IL-1 trap, business.industry, Zymosan, Inflammasome, medicine.disease, Control subjects, NLRP3 inflammasome, IL, interleukin, 030104 developmental biology, chemistry, IL-1β, Immunology, IL-1α, Preclinical Research, medicine.symptom, Cardiology and Cardiovascular Medicine, business, anakinra, medicine.drug |
| الوصف: | Visual Abstract Highlights • Acute pericarditis is characterized by an intense inflammatory response involving the pericardium. Although mostly benign in its clinical course, 30% of patients may experience complications (recurrence, treatment failure, cardiac tamponade). • The pathogenesis of pericarditis is poorly understood. The scarcity of animal models might justify the limited understanding of this syndrome and the lack of targeted therapies. • Acute pericarditis is believed to represent a stereotypical response to an acute injury of the pericardium. The NLRP3 inflammasome, through its main product, IL-1β, could play a central role in the clinical manifestations. • A mouse model of acute pericarditis was developed through the intrapericardial injection of zymosan A, leading to the classical features of the inflamed pericardium: pericardial effusion, pericardial thickening, and increased expression of the NLRP3 inflammasome. By inhibiting the NLRP3 inflammasome or IL-1β, the pericardial effusion and thickening and the NLRP3 inflammasome expression were greatly reduced compared with vehicle. • Treatment with IL-1 trap, neutralizing both IL-1β and IL-1α, produced a powerful effect on pericardial inflammation in the experimental pericarditis model. Summary Human samples of patients with chronic pericarditis and appropriate control subjects were stained for the inflammasome components. A mouse model of pericarditis was developed through the intrapericardial injection of zymosan A. Different inflammasome blockers were tested in the mouse model. Patients with pericarditis presented an intensification of the inflammasome activation compared with control subjects. The experimental model showed the pathological features of pericarditis. Among inflammasome blockers, NLRP3 inflammasome inhibitor, anakinra, and interleukin-1 trap were found to significantly improve pericardial alterations. Colchicine partially improved the pericardial inflammation. An intense activation of the inflammasome in pericarditis was demonstrated both in humans and in mice. |
| تدمد: | 2452-302X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68468ff50da9056d26404bed75d91627Test https://doi.org/10.1016/j.jacbts.2020.11.016Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....68468ff50da9056d26404bed75d91627 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2452302X |
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