Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
| العنوان: | Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review |
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| المؤلفون: | Shilpa Chitnis, Vibhash D. Sharma, Amy W. Amara, Samarpita Sengupta |
| المصدر: | Frontiers in Neurology, Vol 9 (2018) Frontiers in Neurology |
| بيانات النشر: | Frontiers Media SA, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, sleep-wake pathophysiology, Deep brain stimulation, medicine.medical_treatment, Thalamus, Stimulation, Review, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, medicine, lcsh:Neurology. Diseases of the nervous system, Pedunculopontine nucleus, subthalamic nucleus, business.industry, Neurodegeneration, Dopaminergic, medicine.disease, Sleep in non-human animals, deep brain stimulation, Parkinson disease, sleep-wake disturbances, Subthalamic nucleus, 030104 developmental biology, Neurology, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Sleep-wake disturbances are common non-motor manifestations in Parkinson Disease (PD). Complex pathophysiological changes secondary to neurodegeneration in combination with motor symptoms and dopaminergic medications contribute to development of sleep-wake disturbances. The management of sleep complaints in PD is important as this symptom can affect daily activities and impair quality of life. Deep brain stimulation (DBS) is an effective adjunctive therapy for management of motor symptoms in PD. However, its effect on non-motor symptoms including sleep-wake disturbances is not widely understood. In this article, we reviewed studies assessing the effect of DBS at various therapeutic targets on sleep-wake disturbances. Of the studies examining the role of DBS in sleep-wake disturbances, the effect of subthalamic nucleus stimulation is most widely studied and has shown improvement in sleep quality, sleep efficiency, and sleep duration. Although, studies investigating changes in sleep with stimulation of thalamus, globus pallidus interna, and pedunculopontine nucleus are limited, they support the potential for modulation of sleep-wake centers with DBS at these sites. The mechanism by which DBS at different anatomical targets affects sleep-wake disturbances in PD is unclear and may involves multiple factors, including improved motor symptoms, medication adjustment, and direct modulation of sleep-wake centers. |
| تدمد: | 1664-2295 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683cec6da4bb9707412593e9b5854931Test https://doi.org/10.3389/fneur.2018.00697Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....683cec6da4bb9707412593e9b5854931 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642295 |
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