Umbilical cord‐derived MSC and hyperbaric oxygen therapy effectively protected the brain in rat after acute intracerebral haemorrhage
| العنوان: | Umbilical cord‐derived MSC and hyperbaric oxygen therapy effectively protected the brain in rat after acute intracerebral haemorrhage |
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| المؤلفون: | Pei-Hsun Sung, Re-Wen Wu, Tsung-Cheng Yin, Hon-Kan Yip, Kuan-Hung Chen, Kun-Chen Lin, John Y. Chiang |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, CD31, medicine.medical_specialty, CD14, Apoptosis, Inflammation, Mesenchymal Stem Cell Transplantation, HMGB1, medicine.disease_cause, Umbilical cord, neurological function, Umbilical Cord, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Animals, Medicine, Brain Diseases, Hyperbaric Oxygenation, mesenchymal stem cells, biology, business.industry, intracerebral haemorrhage, Original Articles, Cell Biology, Rats, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, hyperbaric oxygen, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Original Article, medicine.symptom, NeuN, business, Intracranial Hemorrhages, Oxidative stress |
| الوصف: | This study tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells (HUCDMSCs) and hyperbaric oxygen (HBO) was superior to either one on preserving neurological function and reducing brain haemorrhagic volume (BHV) in rat after acute intracerebral haemorrhage (ICH) induced by intracranial injection of collagenase. Adult male SD rats (n = 30) were equally divided into group 1 (sham‐operated control), group 2 (ICH), group 3 (ICH +HUCDMSCs/1.2 × 106 cells/intravenous injection at 3h and days 1 and 2 after ICH), group 4 (ICH +HBO/at 3 hours and days 1 and 2 after ICH) and group 5 (ICH +HUCDMSCs‐HBO), and killed by day 28 after ICH. By day 1, the neurological function was significantly impaired in groups 2‐5 than in group 1 (P |
| تدمد: | 1582-4934 1582-1838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67def6a87163b93628e95948fbe02a3dTest https://doi.org/10.1111/jcmm.16577Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....67def6a87163b93628e95948fbe02a3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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