Two Years’ Prospective Collection of Molecular and Epidemiological Data Shows Limited Spread of Hepatitis A Virus outside Risk Groups in Amsterdam, 2000–2002
| العنوان: | Two Years’ Prospective Collection of Molecular and Epidemiological Data Shows Limited Spread of Hepatitis A Virus outside Risk Groups in Amsterdam, 2000–2002 |
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| المؤلفون: | Roel A. Coutinho, Sylvia M. Bruisten, Jim E. van Steenbergen, G.M.S. Tjon, Alex Koek, Anneke van den Hoek |
| المساهمون: | Faculteit der Geneeskunde, Other departments, Infectious diseases, Medical Microbiology and Infection Prevention |
| المصدر: | The Journal of Infectious Diseases, 189(3), 471-482. Oxford University Press Journal of infectious diseases, 189(3), 471-482. Oxford University Press |
| بيانات النشر: | Oxford University Press (OUP), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Genotype, viruses, Molecular Sequence Data, Population, Virus, Men who have sex with men, Epidemiology, Disease Transmission, Infectious, medicine, Humans, Immunology and Allergy, Pakistan, Prospective Studies, Homosexuality, Male, Child, education, Phylogeny, Aged, Netherlands, Molecular Epidemiology, Travel, education.field_of_study, Transmission (medicine), business.industry, Infant, virus diseases, Hepatitis A, Middle Aged, medicine.disease, Virology, Vaccination, Morocco, Infectious Diseases, Child, Preschool, RNA, Viral, Female, business, Hepatitis A Virus, Human |
| الوصف: | We performed a viral sequencing study on samples representing all reported primary cases of acute hepatitis A virus (HAV) infection reported for 2 years in Amsterdam. Two regions of HAV RNA were amplified, sequenced, and used for phylogenetic analysis. Of 156 cases, strains of 104 isolates (66.6%) clustered into 3 genotypes: 1A, 1B, and 3. Two separate transmission circles occurred, without mutual interrelation. In genotype 1A, 4 clusters occurred in men having sex with men (MSM), and the fifth cluster was related to a virus from Morocco. In genotype 1B, 6 small clusters were directly related to the Moroccan virus. In genotype 3, strains were related to a virus from Pakistan. Our analysis indicates that, to stop transmission of HAV in Amsterdam, the entire MSM population and travelers to countries where HAV is endemic, especially children, should be vaccinated. Prevention strategies need not include the vaccination of all children living in Amsterdam. |
| وصف الملف: | application/pdf |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bd7cff2f6c4c8d0d469c01fee8cba2Test https://doi.org/10.1086/381152Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....67bd7cff2f6c4c8d0d469c01fee8cba2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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