Spectrum of CD4 to CD8 T-Cell Ratios in Lymphocytic Alveolitis Associated with Methotrexate-induced Pneumonitis
| العنوان: | Spectrum of CD4 to CD8 T-Cell Ratios in Lymphocytic Alveolitis Associated with Methotrexate-induced Pneumonitis |
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| المؤلفون: | Marie Wislez, Hélène Prigent, Jacques Cadranel, Charles Mayaud, Antoine Parrot, Véronique Boussaud, Claire Fuhrman, Jean-François Bernaudin |
| المصدر: | American Journal of Respiratory and Critical Care Medicine. 164:1186-1191 |
| بيانات النشر: | American Thoracic Society, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, musculoskeletal diseases, Pulmonary and Respiratory Medicine, Adolescent, Lymphocyte, CD4-CD8 Ratio, Critical Care and Intensive Care Medicine, medicine, Humans, heterocyclic compounds, Lymphocytes, skin and connective tissue diseases, Aged, Retrospective Studies, Pneumonitis, medicine.diagnostic_test, Cumulative dose, business.industry, Respiratory disease, Pneumonia, Middle Aged, medicine.disease, Pulmonary Alveoli, Methotrexate, medicine.anatomical_structure, Bronchoalveolar lavage, Toxicity, Immunology, Female, business, Bronchoalveolar Lavage Fluid, medicine.drug |
| الوصف: | The present study was conducted to confirm the presence of severe lymphocytic alveolitis and to determine the factors responsible for the very different alveolar CD4 to CD8 T-cell ratios (CD4/ CD8) described in methotrexate-induced pneumonitis (MTX-pneumonitis). Clinical and radiologic findings, as well as bronchoalveolar lavage (BAL) data, including CD4 and CD8 subset analysis, were retrospectively reviewed for patients hospitalized between 1985 and 2000 for MTX-pneumonitis. BAL cell counts from patients with MTX-pneumonitis (cases) were compared with those from patients receiving MTX but who did not have evidence of MTX toxicity (MTX-exposed patients) and those from healthy subjects (control subjects). Nineteen BAL were performed in 14 consecutive cases of MTX-pneumonitis. MTX was given for various underlying diseases. All cases presented a subacute diffuse interstitial pneumonitis that recovered, with MTX discontinuation and/or initiation of adjunctive steroid therapy. At the time of diagnosis, BAL cell counts in MTX-pneumonitis indicated severe lymphocytic alveolitis when compared with MTX-exposed patients and control subjects and moderate neutrophil alveolitis compared with control subjects. The lymphocytic alveolitis resulted from an increase in both CD4 and CD8 lymphocyte cell counts. Nevertheless, alveolar CD4/ CD8 T-cell ratios ranged from 0.4 to 9.6. CD4/CD8 values correlated positively with lymphocyte counts but negatively with time elapsed between last MTX administration and BAL and with steroid cumulative dose received by the patients. Severe lymphocytic alveolitis was confirmed in our series of MTX-pneumonitis. The between-patient variation in CD4/CD8 T-cell ratios may reflect the large range of time intervals between last MTX administration and BAL evaluation and the use of adjunctive steroid therapy. |
| تدمد: | 1535-4970 1073-449X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c34ce66b820b72db01e6d8319e3a2Test https://doi.org/10.1164/ajrccm.164.7.2010120Test |
| رقم الانضمام: | edsair.doi.dedup.....675c34ce66b820b72db01e6d8319e3a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
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