Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice
| العنوان: | Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice |
|---|---|
| المؤلفون: | Suocheng Hui, Xiaohui Zhu, Xiaolan Wang, Min Zhou, Long Yi, Li Huang, Mantian Mi, Mengting Chen |
| المصدر: | The FASEB Journal. 34:8558-8573 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Bodily Secretions, medicine.medical_specialty, Lithocholic acid, medicine.drug_class, Enteroendocrine Cells, Gut flora, Carbohydrate metabolism, Diet, High-Fat, Biochemistry, Glucagon-Like Peptide-1 Receptor, Receptors, G-Protein-Coupled, Bile Acids and Salts, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glucagon-Like Peptide 1, Internal medicine, Genetics, medicine, Animals, Homeostasis, Glucose homeostasis, Molecular Biology, biology, Bile acid, Chemistry, digestive, oral, and skin physiology, Lipid Metabolism, biology.organism_classification, G protein-coupled bile acid receptor, Glucagon-like peptide-1, Gastrointestinal Microbiome, Transplantation, Glucose, 030104 developmental biology, Endocrinology, Capsaicin, 030217 neurology & neurosurgery, Signal Transduction, Biotechnology |
| الوصف: | Mounting evidence has linked dietary capsaicin (CAP) consumption to the improvement of glucose homeostasis; however, the underlying mechanisms still need to be further elucidated. Male mice were fed a high-fat diet (HFD) with CAP administration for 8 weeks, gut microbiota, bile acid (BA) profiles and markers for BA, and glucose metabolism were investigated. CAP improved glucose homeostasis partially by enhancing the secretion of glucagon-like peptide 1 (GLP-1). The gut microbiota was remodeled by CAP and was characterized by the increased abundance of Bacteroides genera, which is related with lithocholic acid (LCA) production. LCA is an endogenous agonist of Takeda G-protein coupled receptor 5 (TGR5); it may enhance GLP-1 secretion in intestinal L cells. Meanwhile, antibiotics experiment abolished the effects of CAP on glucose homeostasis and microbiota transplantation experiments demonstrated that the CAP-induced beneficial effects were transferable, indicating that the effects of CAP on glucose homeostasis were largely dependent on the gut microbiota. Additionally, we further identified that the improvements induced by CAP were attenuated by the antagonist of GLP-1 receptor, indicating that the activation of GLP-1 signaling contributes to the CAP-induced improvement in glucose homeostasis. |
| تدمد: | 1530-6860 0892-6638 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6741cf61268cd52b46e439e5699d62ceTest https://doi.org/10.1096/fj.201902618rrTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6741cf61268cd52b46e439e5699d62ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
|---|