ATLANTIC DIP: Insulin Therapy for women with IADPSG-diagnosed Gestational Diabetes Mellitus. Does it work?
| العنوان: | ATLANTIC DIP: Insulin Therapy for women with IADPSG-diagnosed Gestational Diabetes Mellitus. Does it work? |
|---|---|
| المؤلفون: | Delia Bogdanet, Breda Kirwan, Oratile Kgosidialwa, Catriona Reddin, Fidelma Dunne, Aoife M. Egan, Louise Carmody |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. :jc.2016-2911 |
| بيانات النشر: | The Endocrine Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Neonatal intensive care unit, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biochemistry, Infant, Newborn, Diseases, Fetal Macrosomia, Cohort Studies, 0302 clinical medicine, Endocrinology, Pre-Eclampsia, Pregnancy, Odds Ratio, Insulin, 030212 general & internal medicine, Obstetrics, Gestational diabetes, Infant, Small for Gestational Age, Female, Cohort study, Adult, Polyhydramnios, medicine.medical_specialty, 030209 endocrinology & metabolism, 03 medical and health sciences, Intensive Care Units, Neonatal, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Retrospective Studies, business.industry, Postpartum Hemorrhage, Biochemistry (medical), Infant, Newborn, Case-control study, nutritional and metabolic diseases, Retrospective cohort study, Hypertension, Pregnancy-Induced, medicine.disease, Hypoglycemia, Pregnancy Complications, Diabetes, Gestational, Logistic Models, Case-Control Studies, Multivariate Analysis, Small for gestational age, Uterine Hemorrhage, business |
| الوصف: | Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using International Association of the Diabetes and Pregnancy Study Group (IADPSG) criteria require insulin therapy.We assessed whether the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT).This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and fetal outcomes were examined.Infants of women with insulin-treated GDM had rates of macrosomia [adjusted odds ratio (aOR), 1.19; 95% confidence interval (CI), 0.87 to 1.63; P = 0.26], large for gestational age (LGA) (aOR, 1.07; 95% CI, 0.77 to 1.47; P = 0.67), and small for gestational age (SGA) (aOR, 0.70; 95% CI, 0.38 to 1.38; P = 0.26) similar to women with NGT. They were more likely to be hypoglycemic at birth (aOR, 6.85; 95% CI, 2.31 to 20.28; P0.01) and to require neonatal intensive care unit care (NICU) (aOR, 12.09; 95% CI, 8.72 to 16.76; P0.01), predominantly for nonmedical reasons. Maternal rates of hypertensive disorders (preeclampsia: aOR, 0.64; 95% CI, 0.34 to 1.12; P = 0.17; pregnancy-induced hypertension: aOR, 1.11; 95% CI, 0.74 to 1.66; P = 0.60) and hemorrhage (ante partum hemorrhage: aOR, 0.56; 95% CI, 0.19 to 1.58; P = 0.27; postpartum hemorrhage: aOR, 1.17; 95% CI, 0.68 to 2.03; P = 0.55) were similar between groups, but the risk of polyhydramnios was increased in the GDM cohort (aOR, 7.75; 95% CI, 3.96 to 15.16; P0.01).Insulin treatment of IADPSG-diagnosed GDM results in rates of macrosomia, LGA, SGA, and maternal hypertensive disorders similar to those of women with NGT. Although NICU admissions are greater in the GDM cohort, they are primarily for nonmedical reasons. Neonatal hypoglycemia and polyhydramnios remain greater among women with insulin-treated GDM. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670fa0cc5f83e912b15005c56237a642Test https://doi.org/10.1210/jc.2016-2911Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....670fa0cc5f83e912b15005c56237a642 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
|---|