Ultra-low radiation dose protocol for CT-guided intrathecal nusinersen injections for patients with spinal muscular atrophy and severe scoliosis
| العنوان: | Ultra-low radiation dose protocol for CT-guided intrathecal nusinersen injections for patients with spinal muscular atrophy and severe scoliosis |
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| المؤلفون: | Krzysztof Milczarek, Olgierd Rowiński, Anna Kostera-Pruszczyk, Anna Fraczek, Dariusz Konecki, Anna Lusakowska, Grzegorz Rosiak |
| المصدر: | Neuroradiology |
| بيانات النشر: | Springer Berlin Heidelberg, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Neurology, Oligonucleotides, Radiation Dosage, 030218 nuclear medicine & medical imaging, CT-guided injections, Muscular Atrophy, Spinal, 03 medical and health sciences, 0302 clinical medicine, Spinal Neuroradiology, Nusinersen, medicine, Humans, Radiology, Nuclear Medicine and imaging, SMA, Child, Injections, Spinal, Neuroradiology, Retrospective Studies, medicine.diagnostic_test, Lumbar puncture, business.industry, Retrospective cohort study, Spinal muscular atrophy, medicine.disease, Scoliosis, Neurology (clinical), Neurosurgery, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Tomography, X-Ray Computed, 030217 neurology & neurosurgery |
| الوصف: | Purpose Intrathecal injection of nusinersen is an approved treatment of spinal muscular atrophy (SMA). CT-guided injection is a method of nusinersen administration in patients with severe scoliosis, in whom standard lumbar puncture is not feasible. The injections are repeated every 4 months for life, and accumulated radiation doses absorbed by the patient can increase the risk of cancer. In this study, we present the results of CT-guided intrathecal nusinersen injections with an ultra-low radiation dose protocol. Methods Eighteen patients (15 adults and three children) in whom standard lumbar puncture was not feasible due to severe scoliosis or spinal stabilization were included in this retrospective study. The first 23 injections were performed with a standard radiation dose protocol and the next 42 injections with an ultra-low-dose protocol. The radiation doses, measured as total dose length product (DLP), were acquired and compared between the protocols. Results Injections were successful in 100% of patients with both ultra-low-dose and standard protocols. The radiation dose, measured as DLP, was 111.2–1100.7 (Me = 248.1) mGy*cm for the standard protocol. For the ultra-low-dose protocol, the dose range was 5.0–54.4 (Me = 26.7) mGy*cm, which was significantly lower than with the standard protocol (p η2 = 0.67). Conclusion Radiation doses can be significantly decreased in the CT-guided injection of nusinersen. The proposed protocol allows for effective CT-guided intrathecal nusinersen administration in patients with SMA and severe scoliosis. |
| اللغة: | English |
| تدمد: | 1432-1920 0028-3940 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e41de75f0072ffe3d5747fe2fd1eecTest http://europepmc.org/articles/PMC7965851Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....65e41de75f0072ffe3d5747fe2fd1eec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321920 00283940 |
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