Breast-Conserving Therapy: Proteases as Risk Factors in Relation to Survival After Local Relapse
| العنوان: | Breast-Conserving Therapy: Proteases as Risk Factors in Relation to Survival After Local Relapse |
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| المؤلفون: | John A. Foekens, Maxime P. Look, Joan Bolt-de Vries, H. A. Peters, Jan G. M. Klijn, Marion E. Meijer-van Gelder |
| المصدر: | Journal of Clinical Oncology. 17:1449-1449 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Mammary gland, Breast Neoplasms, Mastectomy, Segmental, Cathepsin D, Disease-Free Survival, Metastasis, chemistry.chemical_compound, Cytosol, Risk Factors, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Risk factor, Aged, Proportional Hazards Models, Aged, 80 and over, Analysis of Variance, Univariate analysis, business.industry, Middle Aged, medicine.disease, Urokinase-Type Plasminogen Activator, Primary tumor, Neoplasm Proteins, Surgery, Radiation therapy, medicine.anatomical_structure, Receptors, Estrogen, chemistry, Plasminogen activator inhibitor-1, Female, Neoplasm Recurrence, Local, Receptors, Progesterone, business, Plasminogen activator |
| الوصف: | PURPOSE: To evaluate whether cathepsin D, urokinase-type plasminogen activator (uPA), its inhibitor, plasminogen activator inhibitor-1 (PAI-1), or clinical factors can predict which patients are at risk for developing distant metastases after local recurrence (LR). PATIENTS AND METHODS: Of 1,630 patients treated with breast-conserving surgery and radiotherapy of the breast between 1980 and 1992, LR developed in 171 as a first event. From the available primary tumor tissues, we determined the cytosolic levels of cathepsin D, uPA and PAI-1. RESULTS: In patients with LR, a short (≤ 2 years) disease-free interval (DFI) and skin involvement of LR were associated with poor postrelapse distant metastasis-free survival (PR-DMFS, P = .001, both) and postrelapse overall survival (PR-OS; P CONCLUSION: In patients treated with breast-conserving therapy who had LR as a first event, a short DFI and skin involvement were strong indicators for poor PR-DMFS and PR-OS. The proteases studied did not contribute significantly to the final multivariate model. |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659cd6fc51e17ba3676596f5193ce8c7Test https://doi.org/10.1200/jco.1999.17.5.1449Test |
| رقم الانضمام: | edsair.doi.dedup.....659cd6fc51e17ba3676596f5193ce8c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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