Serum markers in early-stage and locally advanced melanoma
| العنوان: | Serum markers in early-stage and locally advanced melanoma |
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| المؤلفون: | Piotr Rutkowski, Hanna Koseła-Paterczyk, Beata Kotowicz, Maria Kowalska, Katarzyna Szamotulska, Iwona Lugowska, Malgorzata Fuksiewicz, Ewa Mierzejewska |
| المصدر: | Tumour Biology |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Vascular Endothelial Growth Factor A, Serum, Cancer Research, medicine.medical_specialty, Pathology, Skin Neoplasms, Angiogenesis, Gastroenterology, Disease-Free Survival, chemistry.chemical_compound, Adipokines, Lectins, Internal medicine, Biomarkers, Tumor, medicine, Humans, Chitinase-3-Like Protein 1, Stage (cooking), Melanoma, Pathological, Early Detection of Cancer, Aged, Neoplasm Staging, Tissue Inhibitor of Metalloproteinase-1, business.industry, Early stage, General Medicine, Middle Aged, Prognosis, medicine.disease, Primary tumor, Vascular endothelial growth factor, Vascular endothelial growth factor A, Matrix Metalloproteinase 9, chemistry, Cutaneous melanoma, Female, Neoplasm Recurrence, Local, business, Research Article |
| الوصف: | The identification of prognostic factors in cutaneous melanoma allows choosing the most effective treatment, especially in group of patients with locoregional disease. Markers related to carcinogenesis and angiogenesis in particular have effect on the course of the disease. The aim of this study was to evaluate clinical utility of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP-2), MMP-9, tissue inhibitors of metalloproteinase 1 (TIMP-1), and YKL-40 in serum of melanoma patients at pathological stages I–III. We included 148 adult patients with melanoma. The median follow-up was 40 months. Disease recurrence was observed in 43 patients; 3-year disease-free survival (DFS) rate was 71.7 %; 35 patients died; and the 3-year overall survival (OS) rate was 85 %. Concentrations of VEGF, MMP-2, MMP-9, TIMP-1, and YKL-40 were measured by ELISA kits. VEGF, MMP-9, TIMP-1, and YKL-40 were significantly higher in group of patients than in controls. Increased concentrations of TIMP-1 were related to patient survival, which in the group of lower and increased TIMP-1, disease-free survival amounted to 81 vs. 61 % (p = 0.014) and overall survival −88 vs. 82 % (p = 0.050), respectively. An increased concentration of YKL-40 was observed in 59 % of patients with ulceration and in 26 % of patients without ulceration (p = 0.012). We have found a clinically significant correlation between YKL-40 and MMP-9 (rho = 0.363; p = 0.004) as well as YKL-40 and VEGF (rho = 0.306; p = 0.018). In melanoma patients at stages I–III, the high concentrations of TIMP-1 in serum predicted adverse prognosis. YKL-40 was associated with ulceration of primary tumor, which is a very important prognostic factor. |
| تدمد: | 1423-0380 1010-4283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653730e9204f4ee857053054af8833a4Test https://doi.org/10.1007/s13277-015-3564-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....653730e9204f4ee857053054af8833a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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