Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts
| العنوان: | Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts |
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| المؤلفون: | Qi-De Lin, Ye Zuo, Yin-Cheng Teng, Jian-Hua Lin, Chuan-Wei Ding |
| المصدر: | Journal of Perinatal Medicine. 37 |
| بيانات النشر: | Walter de Gruyter GmbH, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Lipoproteins, Placenta, medicine.medical_treatment, Thromboplastin, Preeclampsia, Proinflammatory cytokine, Young Adult, Tissue factor, Tissue factor pathway inhibitor, Pre-Eclampsia, Pregnancy, Internal medicine, Plasminogen Activator Inhibitor 1, Fibrinolysis, medicine, Humans, RNA, Messenger, Hypoxia, Cells, Cultured, business.industry, Obstetrics and Gynecology, medicine.disease, Trophoblasts, Endocrinology, Cytokine, medicine.anatomical_structure, Tissue Plasminogen Activator, Pediatrics, Perinatology and Child Health, Immunology, Cytokines, Female, business, Plasminogen activator |
| الوصف: | Objective Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-alpha) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. |
| تدمد: | 1619-3997 0300-5577 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646a71ec845e64d79eea62ce87c11630Test https://doi.org/10.1515/jpm.2009.060Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....646a71ec845e64d79eea62ce87c11630 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16193997 03005577 |
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