Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
| العنوان: | Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer |
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| المؤلفون: | Eiji Shinozaki, Hiroki Osumi, Mariko Ogura, Keisho Chin, Kensei Yamaguchi, Izuma Nakayama, Daisaku Kamiimabeppu, Takeru Wakatsuki, Keitaro Shimozaki, Daisuke Takahari, Akira Ooki |
| المصدر: | Cancer Medicine Cancer Medicine, Vol 10, Iss 24, Pp 8820-8828 (2021) |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Metastasis, metastatic organ, Carcinoembryonic antigen, Internal medicine, medicine, Biomarkers, Tumor, Humans, Radiology, Nuclear Medicine and imaging, Liquid biopsy, Neoplasm Metastasis, Lymph node, RC254-282, Research Articles, Tumor marker, Aged, circulating tumor DNA, Aged, 80 and over, Chemotherapy, biology, liquid biopsy, business.industry, carcinoembryonic antigen, metastatic colorectal cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Clinical Cancer Research, Middle Aged, medicine.disease, digestive system diseases, medicine.anatomical_structure, biology.protein, Biomarker (medicine), Female, business, Colorectal Neoplasms, Research Article |
| الوصف: | Background Circulating tumor DNA (ctDNA) is a biomarker with potential to reflect comprehensive genomic information and overcome intratumor heterogeneity. In contrast, carcinoembryonic antigen (CEA) is a conventional tumor marker for predicting recurrence, survival, and chemotherapeutic efficacy in patients with metastatic colorectal cancer (mCRC). However, the relationship between them remains unclear. Here, the relationship between plasma ctDNA and CEA levels was evaluated to clarify the advantages and disadvantages of their clinical use. Methods A total of 110 patients with mCRC underwent chemotherapy were enrolled. Amplicon‐based plasma genomic profiling of 14 genes that are commonly mutated in CRC by next‐generation sequencing was compared to the CEA level and tumor diameter using Spearman’s correlation coefficient. Results The overall concordance rate between the ctDNA and CEA levels was 75.5% (83/110). The correlation coefficient between the ctDNA and CEA levels was lower in the group of patients without liver and lymph node metastases (r = 0.18, p = 0.44) than in the group of patients with liver metastasis (r = 0.48, p Tumor diameter and ctDNA and CEA levels highly correlated in metastatic colorectal cancer patients with liver metastases. Status of ctDNA and CEA may not be consistent in metastatic colorectal cancer (mCRC) patients without liver metastasis or with low tumor volume. Both results should be considered when deciding a treatment strategy for mCRC patients without liver metastases. |
| اللغة: | English |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6425829bca9ee6799d7d65a0e1c2ba5eTest http://europepmc.org/articles/PMC8683548Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6425829bca9ee6799d7d65a0e1c2ba5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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