Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy
| العنوان: | Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy |
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| المؤلفون: | Hassan Fadavi, Ioannis N. Petropoulos, Teresa Mixcoatl-Zecuatl, Katie E. Frizzi, Georgios Ponirakis, Maryam Ferdousi, Nigel A. Calcutt, Michael Zhang, Corinne G. Jolivalt, Andrew J.M. Boulton, Mitra Tavakoli, Mark Fineman, Nathan Efron, Shazli Azmi, Rayaz A. Malik, Andrew Marshall, Maria Jeziorska, Corinne A. Lee-Kubli |
| المصدر: | Diabetes, vol 66, iss 5 Marshall, A G, Lee-Kubli, C, Azmi, S, Zhang, M, Ferdousi, M, Mixcoatl-Zecuatl, T, Petropoulos, I N, Ponirakis, G, Fineman, M S, Fadavi, H, Frizzi, K, Tavakoli, M, Jeziorska, M, Jolivalt, C G, Boulton, A J M, Efron, N, Calcutt, N A & Malik, R A 2017, ' Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy ', Diabetes, vol. 66, no. 5, pp. 1380-1390 . https://doi.org/10.2337/db16-1181Test Diabetes |
| بيانات النشر: | American Diabetes Association, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Complications, Diabetic neuropathy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Neurodegenerative, Medical and Health Sciences, Rats, Sprague-Dawley, Cornea, chemistry.chemical_compound, 0302 clinical medicine, Diabetic Neuropathies, Receptors, Insulin, 5-HT2A, 2.1 Biological and endogenous factors, Receptor, Serotonin, 5-HT2A, Aetiology, Analgesics, Symporters, Blotting, Pain Research, Diabetes, Middle Aged, 3. Good health, Allodynia, medicine.anatomical_structure, Spinal Cord, Zucker, Hyperalgesia, Anesthesia, Neurological, Female, Chronic Pain, medicine.symptom, Western, Type 2, Type 1, Receptor, Adult, Serotonin, medicine.medical_specialty, Blotting, Western, 030209 endocrinology & metabolism, Duloxetine Hydrochloride, Diabetes Mellitus, Experimental, Experimental, Endocrinology & Metabolism, 03 medical and health sciences, Clinical Research, Diabetes mellitus, Internal medicine, Journal Article, Diabetes Mellitus, Internal Medicine, medicine, Animals, Humans, Hypoglycemic Agents, Duloxetine, Peripheral Neuropathy, Metabolic and endocrine, Aged, Type 1 diabetes, GABA-A, business.industry, Neurosciences, Neural Inhibition, Receptors, GABA-A, medicine.disease, Spinal cord, Rats, Zucker, Rats, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Case-Control Studies, Sprague-Dawley, business, 030217 neurology & neurosurgery |
| الوصف: | Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Impaired RDD and allodynia were present in type 1 and type 2 diabetic rats but not in rats with type 1 diabetes receiving insulin supplementation that did not restore normoglycemia. Impaired RDD in diabetic rats was rapidly normalized by spinal delivery of duloxetine acting via 5-hydroxytryptamine type 2A receptors and temporally coincident with the alleviation of allodynia. Deficits in RDD and corneal nerve density were demonstrated in patients with painful diabetic neuropathy compared with healthy control subjects and patients with painless diabetic neuropathy. Spinal inhibitory dysfunction and peripheral small fiber pathology may contribute to the clinical phenotype in painful diabetic neuropathy. Deficits in RDD may help identify patients with spinally mediated painful diabetic neuropathy who may respond optimally to therapies such as duloxetine. |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d87bc1c749669ebdf6cdeb434f8cfdTest https://doi.org/10.2337/db16-1181Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....63d87bc1c749669ebdf6cdeb434f8cfd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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