ATG12–ATG3 connects basal autophagy and late endosome function
| العنوان: | ATG12–ATG3 connects basal autophagy and late endosome function |
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| المؤلفون: | Jayanta Debnath, Lyndsay M. Murrow |
| المصدر: | Autophagy, vol 11, iss 6 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | late endosome, Biochemistry & Molecular Biology, Endosome, ATG12, 1.1 Normal biological development and functioning, Viral budding, Endosomes, Biology, Exosome, Autophagic Puncta, PDCD6IP/Alix, Underpinning research, Organelle, Autophagy, exosome, 2.1 Biological and endogenous factors, Animals, Humans, Secretion, viral budding, Amino Acid Sequence, Aetiology, Molecular Biology, Late endosome, PDCD6IP, Cell Biology, Cell biology, Alix, Ubiquitin-Conjugating Enzymes, Small Ubiquitin-Related Modifier Proteins, ATG3, Biochemistry and Cell Biology, Microtubule-Associated Proteins, basal autophagy |
| الوصف: | In addition to supporting cell survival in response to starvation or stress, autophagy promotes basal protein and organelle turnover. Compared to our understanding of stress-induced autophagy, little is known about how basal autophagy is regulated and how its activity is coordinated with other cellular processes. We recently identified a novel interaction between the ATG12-ATG3 conjugate and the ESCRT-associated protein PDCD6IP/Alix that promotes basal autophagy and endolysosomal trafficking. Moreover, ATG12-ATG3 is required for diverse PDCD6IP-mediated functions including late endosome distribution, exosome secretion, and viral budding. Our results highlight the importance of late endosomes for basal autophagic flux and reveal distinct roles for the core autophagy proteins ATG12 and ATG3 in controlling late endosome function. |
| وصف الملف: | application/pdf |
| تدمد: | 1554-8635 1554-8627 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638170873b8855f2c3815ec1bfee6af1Test https://doi.org/10.1080/15548627.2015.1040976Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....638170873b8855f2c3815ec1bfee6af1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15548635 15548627 |
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