Pregnancy in Patients with Type One Diabetes Mellitus Treated with Continuous Subcutaneous Insulin Infusion—Preconception Basal Insulin Dose as a Potential Risk Factor for Fetal Overgrowth?
| العنوان: | Pregnancy in Patients with Type One Diabetes Mellitus Treated with Continuous Subcutaneous Insulin Infusion—Preconception Basal Insulin Dose as a Potential Risk Factor for Fetal Overgrowth? |
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| المؤلفون: | Marina Ivanišević, Maja Baretić, Dubravka Jurišić-Eržen, Gloria Lekšić |
| المصدر: | International Journal of Environmental Research and Public Health Volume 17 Issue 18 International Journal of Environmental Research and Public Health, Vol 17, Iss 6566, p 6566 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Insulin pump, medicine.medical_specialty, endocrine system diseases, Health, Toxicology and Mutagenesis, Birth weight, Pregnancy in Diabetics, lcsh:Medicine, 030209 endocrinology & metabolism, type one diabetes mellitus, pregnancy, preconception, insulin pump, large-for-gestational-age neonates, Article, Fetal Macrosomia, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, Statistical significance, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Retrospective Studies, Glycated Hemoglobin, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija, lcsh:R, Public Health, Environmental and Occupational Health, Infant, Newborn, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics, nutritional and metabolic diseases, Retrospective cohort study, medicine.disease, Diabetes Mellitus, Type 1, Basal (medicine), Female, business, Body mass index |
| الوصف: | Despite widespread use of technology, type one diabetes mellitus (T1DM) is still a great clinical challenge during pregnancy. This study aims to assess how prenatal variables of T1DM patients using continuous subcutaneous insulin infusion (CSII) influence pregnancy outcomes. We performed a retrospective study of 35 patients with T1DM treated with CSII during pregnancy. Alterable preconception variables (A1C, body mass index, basal and bolus insulin dose) were analysed as possible contributors to birth weight and large-for-gestational-age (LGA) prevalence. Inclusion criteria were presence of T1DM for more than two years, A1C < 7.4% and treatment with CSII for at least three months prior to conception. The preconception basal insulin dose and A1C had a significant correlation to the neonatal birth weight (p = 0.01, r = 0.4 and p = 0.04, r = 0.3, respectively) and were significant in regression analysis together contributing 22% of the variance in birth weight percentiles (sig = 0.17, R square = 0.22). Prevalence of LGA was 46%. Women who had LGA neonates also had a higher preconception basal insulin dose compared to women with non-LGA neonates (26 ± 9 vs. 18 ± 7 IU (international units), p = 0.01). The LGA group had a higher preconception A1C, but it did not reach statistical significance (6.5 ± 0.5% vs. 6.2 ± 0.9%, respectively, p = 0.2). Women with T1DM treated with CSII who had unregulated glycaemia and more basal insulin were at greater risk for development of LGA neonates. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-4601 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fc97a67181f775a98987f0f8e26a3aTest https://repository.medri.uniri.hr/islandora/object/medri:3833Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....62fc97a67181f775a98987f0f8e26a3a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16604601 |
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