C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanism
| العنوان: | C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanism |
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| المؤلفون: | John Wahren, John Pernow, Bo-Lennart Johansson |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 285:E864-E870 |
| بيانات النشر: | American Physiological Society, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Male, Nitroprusside, medicine.medical_specialty, Physiology, Vasodilator Agents, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Hemodynamics, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Physiology (medical), Internal medicine, medicine, Humans, Insulin, Infusions, Intravenous, Proinsulin, omega-N-Methylarginine, C-Peptide, biology, C-peptide, business.industry, Blood flow, Acetylcholine, body regions, Nitric oxide synthase, Forearm, Diabetes Mellitus, Type 1, Endocrinology, chemistry, Regional Blood Flow, biology.protein, Omega-N-Methylarginine, Nitric Oxide Synthase, business, Blood Flow Velocity |
| الوصف: | Proinsulin C-peptide has been shown to increase muscle blood flow in type 1 diabetic patients. The underlying mechanism is not fully understood. The aim of this study was to evaluate if the vasodilator effect of C-peptide is mediated by nitric oxide (NO). Eleven type 1 diabetic patients were studied two times and randomized to administration of intravenous and intra-arterial infusion of C-peptide or saline. Forearm blood flow (FBF) was measured by venous occlusion plethysmography during infusion of C-peptide or saline before, during, and after NO synthase (NOS) blockade. Endothelium-dependent and -independent vasodilatation was evaluated by administration of acetylcholine and sodium nitroprusside, respectively. FBF increased by 35% during intravenous C-peptide ( P < 0.01) but not during saline infusion (–2%, not significant). NOS blockade resulted in a more pronounced reduction in FBF during intravenous C-peptide than during saline infusion (–41 vs. –26%, P < 0.05). Intra-arterial C-peptide failed to increase FBF during NOS blockade. However, when C-peptide was given after the recovery from NOS blockade, FBF rose by 30% ( P < 0.001). The vasodilator effects of acetylcholine and nitroprusside were not influenced by C-peptide. It is concluded that the stimulatory effect of C-peptide on FBF in type 1 diabetic patients is mediated via the NO system and that C-peptide increases basal endothelial NO levels. |
| تدمد: | 1522-1555 0193-1849 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a534ceaec36ae9d5bf70bfd4b257d4Test https://doi.org/10.1152/ajpendo.00001.2003Test |
| رقم الانضمام: | edsair.doi.dedup.....62a534ceaec36ae9d5bf70bfd4b257d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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