Exercise and insulin resistance in PCOS: muscle insulin signalling and fibrosis
| العنوان: | Exercise and insulin resistance in PCOS: muscle insulin signalling and fibrosis |
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| المؤلفون: | Boyd Josef Gimnicher Strauss, Samantha K. Hutchison, Samantha Cassar, Nicholas Hatzirodos, Anju E. Joham, Cheryce L. Harrison, Alba Moreno-Asso, Nigel K. Stepto, Danielle Hiam, Benedict J. Canny, Helena J. Teede, Raymond J. Rodgers, Melanie Gibson-Helm |
| المصدر: | Endocrine Connections, Vol 9, Iss 4, Pp 346-359 (2020) Endocrine Connections |
| بيانات النشر: | Bioscientifica, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | collagen, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, high intensity interval training, lcsh:Diseases of the endocrine glands. Clinical endocrinology, hyperandrogenism, Endocrinology, Insulin resistance, Downregulation and upregulation, Fibrosis, Internal medicine, Internal Medicine, medicine, Glucose homeostasis, Aerobic exercise, Mechanistic target of rapamycin, Uncategorized, mechanistic target of rapamysin (mtor), lcsh:RC648-665, biology, business.industry, transforming growth factor β receptor 2 (tgfbrii), Research, Hyperandrogenism, nutritional and metabolic diseases, medicine.disease, Polycystic ovary, treadmill exercise training, biology.protein, typical and atypical protein kinase c, business |
| الوصف: | Objective Mechanisms of insulin resistance in polycystic ovary syndrome (PCOS) remain ill defined, contributing to sub-optimal therapies. Recognising skeletal muscle plays a key role in glucose homeostasis we investigated early insulin signalling, its association with aberrant transforming growth factor β (TGFβ)-regulated tissue fibrosis. We also explored the impact of aerobic exercise on these molecular pathways. Methods A secondary analysis from a cross-sectional study was undertaken in women with (n = 30) or without (n = 29) PCOS across lean and overweight BMIs. A subset of participants with (n = 8) or without (n = 8) PCOS who were overweight completed 12 weeks of aerobic exercise training. Muscle was sampled before and 30 min into a euglycaemic-hyperinsulinaemic clamp pre and post training. Results We found reduced signalling in PCOS of mechanistic target of rapamycin (mTOR). Exercise training augmented but did not completely rescue this signalling defect in women with PCOS. Genes in the TGFβ signalling network were upregulated in skeletal muscle in the overweight women with PCOS but were unresponsive to exercise training except for genes encoding LOX, collagen 1 and 3. Conclusions We provide new insights into defects in early insulin signalling, tissue fibrosis, and hyperandrogenism in PCOS-specific insulin resistance in lean and overweight women. PCOS-specific insulin signalling defects were isolated to mTOR, while gene expression implicated TGFβ ligand regulating a fibrosis in the PCOS-obesity synergy in insulin resistance and altered responses to exercise. Interestingly, there was little evidence for hyperandrogenism as a mechanism for insulin resistance. |
| اللغة: | English |
| تدمد: | 2049-3614 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629a8acf05a9932b0bcdc691d307a36eTest https://ec.bioscientifica.com/view/journals/ec/9/4/EC-19-0551.xmlTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....629a8acf05a9932b0bcdc691d307a36e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20493614 |
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