Polyphenols Have No Impact on Endothelial Function in Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial
| العنوان: | Polyphenols Have No Impact on Endothelial Function in Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial |
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| المؤلفون: | Maria Carmen Martinez, Khaled Messaoudi, Sylvain Recoquillon, Astrid Darsonval, N. Meslier, Samir Henni, Frédéric Gagnadoux, Ramaroson Andriantsitohaina, Pascaline Priou, Wojciech Trzepizur, Jean-François Hamel, Vanessa Bironneau |
| المساهمون: | Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de pneumologie, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre de recherche clinique, Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Pharmacie, Micro et Nanomédecines Biomimétiques, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Mitochondrie : Régulations et Pathologie, Biologie Neurovasculaire Intégrée (BNVI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Micro et Nanomédecines Biomimétiques (MINT) |
| المصدر: | Journal of Nutrition Journal of Nutrition, American Society for Nutrition, 2018, 148 (4), pp.581-586. ⟨10.1093/jn/nxy005⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), Hyperemia, 030204 cardiovascular system & hematology, Placebo, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Heart Rate, Internal medicine, Heart rate, medicine, Humans, Vitis, Continuous positive airway pressure, Endothelial dysfunction, Reactive hyperemia, ComputingMilieux_MISCELLANEOUS, Sleep Apnea, Obstructive, Nutrition and Dietetics, Continuous Positive Airway Pressure, business.industry, Sleep apnea, Polyphenols, Middle Aged, medicine.disease, Atherosclerosis, 3. Good health, Obstructive sleep apnea, Blood pressure, 030228 respiratory system, Fruit, Cardiology, Female, Endothelium, Vascular, business |
| الوصف: | Background Endothelial dysfunction, a pathophysiologic determinant of atherogenesis, has been found to occur in obstructive sleep apnea syndrome (OSA) and is improved by continuous positive airway pressure (CPAP). However, the efficacy of CPAP therapy is limited by variable adherence. Alternative treatment strategies are needed. The impact of polyphenols on endothelial function has never been evaluated in OSA. Objective We evaluated the impact of 1-mo supplementation with grape juice polyphenols (GJPs) on the reactive hyperemia index (RHI), a validated measure of endothelial function in patients with severe OSA. Methods Forty participants [75% men, median (IQR) age: 61 y (34, 64 y), BMI (in kg/m2): 30.6 (20.9, 33.7)] with severe OSA [median apnea-hypopnea index 43/h (33/h, 56/h)] were randomly assigned to receive GJPs (300 mg/d; n = 20) or placebo (n = 20) for 1 mo. The primary outcome was the change in RHI between baseline and after 1 mo of GJPs or placebo. Secondary outcome measures included changes in blood pressure (BP), heart rate (HR), and polysomnographic indexes. Results No significant differences in RHI and BP outcomes were observed between the GJPs and placebo groups. A significant between-group difference was observed for HR changes [-1 bpm (-5, +5 bpm) in the GJPs group compared with +6 bpm (+3, +10 bpm) in the placebo group; P = 0.001]. A significant decrease in total sleep time was observed in the GJPs group compared with the placebo group [-10 min (-33, 6 min) compared with +15 min (-12, 40 min), respectively; P = 0.02], with no between-group differences in the distribution of sleep stages. Conclusions In participants with severe OSA and no overt cardiovascular disease, 1-mo GJP supplementation had no effect on endothelial function. This trial was registered at clinicaltrials.gov as NCT01977924. |
| اللغة: | English |
| تدمد: | 0022-3166 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f7d96ced0e0a57308c6886af9ea8daTest https://hal.archives-ouvertes.fr/hal-02323309Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61f7d96ced0e0a57308c6886af9ea8da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00223166 |
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