Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study
| العنوان: | Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study |
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| المؤلفون: | Anna A.H. Mertens, Jacques Devière, Jacques J. Bergman, Caterina Guidone, Cormac Magee, Guido Costamagna, David L. Hopkins, Annieke van Baar, Paulina Vignolo, Rehan Haidry, Max Nieuwdorp, Raf Bisschops, Laurent Crenier, Jan G.P. Tijssen, Frits Holleman, Leonardo Rodriguez Grunert, Bu'Hussain Hayee, Manoel Galvao Neto |
| المساهمون: | Gastroenterology and Hepatology, Graduate School, ACS - Diabetes & metabolism, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, General Internal Medicine, Cardiology, Vascular Medicine, ACS - Heart failure & arrhythmias |
| المصدر: | Gut, 69(2), 295-303. BMJ Publishing Group Gut |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | endoscopic procedures, therapeutic endoscopy, medicine.medical_specialty, glucose metabolism, medicine.medical_treatment, duodenal mucosa, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Weight loss, Internal medicine, Diabetes mellitus, Gastro-entérologie, Medicine, 030212 general & internal medicine, Adverse effect, business.industry, Repeated measures design, Endoscopy, medicine.disease, Therapeutic endoscopy, diabetes mellitus, Homeostatic model assessment, 030211 gastroenterology & hepatology, medicine.symptom, business, Body mass index |
| الوصف: | Background: The duodenum has become a metabolic treatment target through bariatric surgery learnings and the specific observation that bypassing, excluding or altering duodenal nutrient exposure elicits favourable metabolic changes. Duodenal mucosal resurfacing (DMR) is a novel endoscopic procedure that has been shown to improve glycaemic control in people with type 2 diabetes mellitus (T2D) irrespective of body mass index (BMI) changes. DMR involves catheter-based circumferential mucosal lifting followed by hydrothermal ablation of duodenal mucosa. This multicentre study evaluates safety and feasibility of DMR and its effect on glycaemia at 24 weeks and 12 months. Methods: International multicentre, open-label study. Patients (BMI 24-40) with T2D (HbA1c 59-86 mmol/mol (7.5%-10.0%)) on stable oral glucose-lowering medication underwent DMR. Glucose-lowering medication was kept stable for at least 24 weeks post DMR. During follow-up, HbA1c, fasting plasma glucose (FPG), weight, hepatic transaminases, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), adverse events (AEs) and treatment satisfaction were determined and analysed using repeated measures analysis of variance with Bonferroni correction. Results: Forty-six patients were included of whom 37 (80%) underwent complete DMR and 36 were finally analysed; in remaining patients, mainly technical issues were observed. Twenty-four patients had at least one AE (52%) related to DMR. Of these, 81% were mild. One SAE and no unanticipated AEs were reported. Twenty-four weeks post DMR (n=36), HbA1c (-10±2 mmol/mol (-0.9%±0.2%), p SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf; Print-Electronic |
| تدمد: | 1468-3288 0017-5749 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c68f262d95a0b628d97c027b56a180Test https://doi.org/10.1136/gutjnl-2019-318349Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61c68f262d95a0b628d97c027b56a180 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683288 00175749 |
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