Paired-pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala
| العنوان: | Paired-pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala |
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| المؤلفون: | Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari |
| المصدر: | Basic and Clinical Neuroscience Journal. 12:827-836 |
| بيانات النشر: | Negah Scientific Publisher, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Clinical neuroscience, Pulse (signal processing), Dentate gyrus, Molecular neuroscience, Orexin receptor, Cellular and Molecular Neuroscience, medicine.anatomical_structure, nervous system, Disinhibition, Cellular neuroscience, medicine, Neurology (clinical), medicine.symptom, Neuroscience, Basolateral amygdala |
| الوصف: | The Basolateral Amygdala (BLA) substantially affects neuronal transmission and synaptic plasticity processes through the dentate gyrus. Orexin neuropeptides play different roles in the sleep/wakefulness cycle, feeding, learning, and memory. The present study aimed to investigate the function of the orexin receptors of the BLA in the hippocampal local interneuron circuits.For this, the region's paired-pulse responses from the Dentate Gyrus (DG) were recorded. Within the procedure, SB-334867-A (12μg/0.5μL) and TCS-OX2-29 (10μg/0.5μL (orexin 12 receptors antagonists, respectively), were administered into both sides of the BLA areas of the rat brain. Dimethyl Sulfoxide (DMSO) was used as the solvent in the control animals with a volume of 0.5μL.Our data indicated that the Paired-pulse (PP) responses were not affected by the inactivation of the orexin receptors of the BLA.Due to not observing any significant changes in the short form of synaptic plasticity, after inactivation of the orexin system of the BLA, we hypothesize that the orexinergic fibers to the basolateral part of the amygdala influence the long-term synaptic efficacy; however, the primary processing of information in short-term plasticity model is not affected by the same system. The elementary processing of the data by the amygdala might happen through the action of other neurotransmitter systems.The neuronal transmission of DG following orexin receptors antagonism of the BLA.Paired-pulse responses were not affected by the orexin 1 receptors antagonism.Paired-pulse responses were not affected by the orexin 2 receptors antagonism.The orexinergic system has modulatory effects by sending projection fibers to several parts of the brain, such as the hippocampus and amygdala. Orexin neuropeptides activate basolateral amygdala neural circuits during different arousal states. Although, this system plays a vital role in creating appropriate behavioral reactions, the primary processing of the information in short-term plasticity model is not affected by it. |
| تدمد: | 2008-126X 2228-7442 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a5724f3ff4022d92634fa870cb0e7bTest https://doi.org/10.32598/bcn.12.6.1460.1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61a5724f3ff4022d92634fa870cb0e7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2008126X 22287442 |
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