Liprins in oncogenic signaling and cancer cell adhesion
| العنوان: | Liprins in oncogenic signaling and cancer cell adhesion |
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| المؤلفون: | Ivan de Curtis, Outi Monni, Henna Pehkonen |
| المساهمون: | Pehkonen, H, de Curtis, I, Monni, O. |
| المصدر: | Oncogene |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Scaffold protein, Cancer Research, Review Article, Protein tyrosine phosphatase, Biology, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Nuclear Matrix-Associated Proteins, Neoplasms, Biomarkers, Tumor, Cell Adhesion, Genetics, medicine, Humans, Cell adhesion, Molecular Biology, 030304 developmental biology, 0303 health sciences, Cancer, Oncogenes, medicine.disease, Review article, Gene Expression Regulation, Neoplastic, Focal adhesion, Tumor progression, Multigene Family, 030220 oncology & carcinogenesis, Cancer cell, Disease Progression, Neuroscience, Signal Transduction |
| الوصف: | Liprins are a multifunctional family of scaffold proteins, identified by their involvement in several important neuronal functions related to signaling and organization of synaptic structures. More recently, the knowledge on the liprin family has expanded from neuronal functions to processes relevant to cancer progression, including cell adhesion, cell motility, cancer cell invasion, and signaling. These proteins consist of regions, which by prediction are intrinsically disordered, and may be involved in the assembly of supramolecular structures relevant for their functions. This review summarizes the current understanding of the functions of liprins in different cellular processes, with special emphasis on liprins in tumor progression. The available data indicate that liprins may be potential biomarkers for cancer progression and may have therapeutic importance. |
| تدمد: | 1476-5594 0950-9232 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617399a093fffbc287b34dc173961c33Test https://doi.org/10.1038/s41388-021-02048-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....617399a093fffbc287b34dc173961c33 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765594 09509232 |
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