A mathematical model for predicting the adult height of girls with idiopathic central precocious puberty: A European validation
| العنوان: | A mathematical model for predicting the adult height of girls with idiopathic central precocious puberty: A European validation |
|---|---|
| المؤلفون: | Raja Brauner, Pierre Lemaire, Dick Mul, Gwénaëlle Duhil de Bénazé, Wilma Oostdijk, Sabine Heger |
| المساهمون: | ROSP (G-SCOP_ROSP), Laboratoire des sciences pour la conception, l'optimisation et la production (G-SCOP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Fondation Ophtalmologique Adolphe de Rotschild, Université Paris Descartes - Paris 5 (UPD5), Diabeter, centre for pediatric and adolescent diabetes care and research, Hannover Medical School [Hannover] (MHH), Department of Pediatrics, Leiden University Medical Center, Recherche Opérationnelle pour les Systèmes de Production (G-SCOP_ROSP ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| المصدر: | PLoS ONE PLoS ONE, Public Library of Science, 2018, 13 (10), ⟨10.1371/journal.pone.0205318⟩ PLoS ONE, Vol 13, Iss 10, p e0205318 (2018) |
| بيانات النشر: | Public Library of Science, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Pediatrics, European People, Physiology, Peptide Hormones, German People, lcsh:Medicine, Puberty, Precocious, Biochemistry, Gonadotropin-Releasing Hormone, 0302 clinical medicine, Endocrinology, Mathematical and Statistical Techniques, Pediatric Endocrinology, Germany, Medicine and Health Sciences, Ethnicities, lcsh:Science, Child, Idiopathic central precocious puberty, ComputingMilieux_MISCELLANEOUS, Netherlands, [STAT.AP]Statistics [stat]/Applications [stat.AP], Multidisciplinary, Mathematical Models, Statistics, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Adult height, Physical Sciences, Female, Research Article, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Research and Analysis Methods, 03 medical and health sciences, 030225 pediatrics, medicine, Humans, Statistical Methods, Dutch People, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Endocrine Physiology, business.industry, lcsh:R, Puberty, Biology and Life Sciences, Luteinizing Hormone, Models, Theoretical, Hormones, Body Height, People and Places, lcsh:Q, Population Groupings, Treatment decision making, Follicle Stimulating Hormone, business, Mathematics, Forecasting |
| الوصف: | Background A previous single-center study established a mathematical model for predicting the adult height (AH) in girls with idiopathic central precocious puberty (CPP). Objective To perform internal and external validations by comparing the actual AH to the calculated AH established by this model and to update it. Methods The original formula, calculated AH (cm) = 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1.83 (luteinizing hormone/follicle-stimulating hormone peaks ratio) + 159.68, was established in a sample of 134 girls (group 4) and was applied to additional girls with CPP seen in the same center (group 1, n = 35), in Germany (group 2, n = 43) and in the Netherlands (group 3, n = 72). This formula has been updated based on these extended data, and both versions are available at the following location: http://www.kamick.org/lemaire/med/girls-cpp15.htmlTest. Results Despite the differences among the 4 groups in terms of their characteristics at the initial evaluation and the percentages of patients treated with the gonadotropin-releasing hormone analogue, they have similar calculated and actual AHs. The actual AHs are 162.2±7.0, 163.0±7.6, 162.4±7.7 and 162.1±5.6 cm in groups 1 to 4, respectively. They are highly correlated with the AHs calculated by the formula established in the original group (group 4), with R at 0.84, 0.67 and 0.69 in groups 1 to 3, respectively. When the actual AHs and the AHs predicted by the Bayley and Pinneau method are compared, the R is 0.76, 0.51 and 0.64 in groups 1 to 3, respectively. The absolute differences between actual AHs and the calculated AHs are greater than 1 SD (5.6 cm) in 15%, 35% and 28% of the patients in groups 1 to 3, respectively. Conclusion This study validates and updates the previously established formula for predicting AH in girls with CPP. This updated formula can help clinicians to make treatment decisions. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613eb9249da6813f52ee4499a4efc0d5Test http://europepmc.org/articles/PMC6178384Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....613eb9249da6813f52ee4499a4efc0d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|