Lack of Pharmacokinetic Drug Interaction between Tenofovir Disoproxil Fumarate and Nelfinavir Mesylate
| العنوان: | Lack of Pharmacokinetic Drug Interaction between Tenofovir Disoproxil Fumarate and Nelfinavir Mesylate |
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| المؤلفون: | Lijie Zhong, Marta Boffito, Chris Higgs, Jaymin Shah, Anita Mathias, Anton Pozniak, Brian P. Kearney |
| المصدر: | Antimicrobial Agents and Chemotherapy. 49:4386-4389 |
| بيانات النشر: | American Society for Microbiology, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Tenofovir, Organophosphonates, Pharmacology, Pharmacokinetics, immune system diseases, Healthy volunteers, Humans, Medicine, Pharmacology (medical), Nelfinavir, Reverse-transcriptase inhibitor, business.industry, Adenine, virus diseases, HIV Protease Inhibitors, biochemical phenomena, metabolism, and nutrition, Drug interaction, Infectious Diseases, Area Under Curve, Reverse Transcriptase Inhibitors, Drug Therapy, Combination, Female, Once daily, business, Nelfinavir mesylate, medicine.drug |
| الوصف: | A study explored the pharmacokinetics of tenofovir (300 mg administered once daily) and nelfinavir (1,250 mg twice daily) when coadministered in 29 healthy volunteers. Tenofovir, nelfinavir, and M8 pharmacokinetics was unaltered when tenofovir and nelfinavir were coadministered, and tenofovir administration did not affect the M8/nelfinavir area under the concentration-versus-time curve over the dosing interval (AUCtau) ratio. No interaction between tenofovir and nelfinavir was observed. |
| تدمد: | 1098-6596 0066-4804 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ee980a81484ec3218aaa368825b07fTest https://doi.org/10.1128/aac.49.10.4386-4389.2005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....60ee980a81484ec3218aaa368825b07f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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