Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes
| العنوان: | Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes |
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| المؤلفون: | Gidon J. Bönhof, Dan Ziegler, J Szendrödi, Sonja Püttgen, Stefan Lehr, Alexander Strom, Karsten Müssig, Martin Röhling, Kálmán Bódis, Daniel F. Markgraf, Michael Roden |
| المصدر: | Diabetes Care. 40:246-252 |
| بيانات النشر: | American Diabetes Association, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Heart Diseases, Endocrinology, Diabetes and Metabolism, Physical fitness, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Autonomic Nervous System, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Heart Rate, Germany, Diabetes mellitus, Internal medicine, Heart rate, Electric Impedance, Internal Medicine, medicine, Humans, Heart rate variability, Prospective Studies, Aged, Glycated Hemoglobin, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, Cardiorespiratory fitness, Middle Aged, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Endocrinology, Autonomic Nervous System Diseases, Cardiorespiratory Fitness, Diabetes Mellitus, Type 2, Creatinine, Cardiology, Female, Insulin Resistance, business |
| الوصف: | OBJECTIVEBoth impaired cardiorespiratory fitness (CRF) and heart rate variability (HRV) are predictors of mortality, but their relative roles in recent-onset diabetes are unknown. We determined to which extent CRF and HRV are reduced and interrelated in recent-onset diabetes.RESEARCH DESIGN AND METHODSParticipants from the German Diabetes Study with type 1 (n = 163) or type 2 (n = 188) diabetes with known diabetes duration RESULTSCompared with control subjects, patients with type 2 diabetes showed reduced VO2max (median [1st–3rd quartiles] 19.3 [16.5–22.9] vs. 25.6 [20.7–29.9] mL/kg body weight/min; P < 0.05), diminished VCO2max (23.0 [19.1–26.8] vs. 30.9 [24.5–34.4] mL/kg body weight/min; P < 0.05), blunted heart rate recovery after 2 min (−29.0 [−35.0 to −23.0] vs. −36.0 [−42.8 to −28.0] beats/min; P < 0.05), and reduced HRV in four of nine indices, whereas patients with type 1 diabetes had unaltered CRF but reduced HRV in three of nine indices (P < 0.05), indicating diminished vagal and sympathetic HRV modulation. HRV measures correlated with VO2max in patients with type 1 diabetes (r >0.34; P < 0.05) but not in those with type 2 diabetes.CONCLUSIONSCRF is reduced in recently diagnosed type 2 diabetes but preserved in type 1 diabetes, whereas cardiac autonomic function is reduced in both diabetes types but is strongly associated with CRF only in type 1 diabetes. These results support the therapeutic concept of promoting physical fitness in the early course of diabetes. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c810936dc36983619b3612929b341aTest https://doi.org/10.2337/dc16-1898Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....60c810936dc36983619b3612929b341a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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