Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions
| العنوان: | Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions |
|---|---|
| المؤلفون: | Martyna Szczyrek, Joanna Boresowicz, Magdalena Kowalewska, Mateusz Bujko, Artur Kowalik, Angelika Długosz, Kamil Zalewski, Stanisław Góźdź, Krzysztof Goryca |
| المصدر: | Diagnostics Diagnostics, Vol 11, Iss 1706, p 1706 (2021) Volume 11 Issue 9 |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Medicine (General), endocrine system, Vulvar Squamous Cell Carcinoma, Clinical Biochemistry, Cell, differentiated vulvar intraepithelial neoplasia, Article, R5-920, medicine, In patient, Differentiated Vulvar Intraepithelial Neoplasia, Plasma samples, integumentary system, business.industry, vulvar carcinoma, female genital diseases and pregnancy complications, Circulating MicroRNA, medicine.anatomical_structure, Potential biomarkers, Vulvar Carcinoma, circulating microRNA, miR-431-5p, high-grade squamous intraepithelial lesion, business |
| الوصف: | Vulvar squamous cell carcinoma (VSCC) develops from high-grade squamous intraepithelial lesions (HSIL) and differentiated vulvar intraepithelial neoplasia (dVIN). This study aimed to assess the diagnostic value of circulating hsa-miR-431-5p in vulvar precancers and VSCC. Expression levels of hsa-miR-431-5p were analyzed by quantitative RT-PCR in plasma samples of 29 patients with vulvar precancers (HSIL or dVIN), 107 with VSCC as well as 15 healthy blood donors. We used hsa-miR-93-5p and hsa-miR-425-5p as normalizers. The levels of miR-431-5p were increased in the blood of patients with VSCC compared to those with vulvar precancers. Statistically significant differences in the survival rates (time to progression) were revealed for VSCC patients categorized by miR-431-5p levels. Low levels of circulating miR-431-5p were found to be indicative of unfavorable survival rates. In summary, our data reveal the diagnostic potential of circulating miR-431-5p in patients with vulvar precancers and VSCC. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2075-4418 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffdee19171c1d49e6898f7d36bb190bTest http://europepmc.org/articles/PMC8465739Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ffdee19171c1d49e6898f7d36bb190b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20754418 |
|---|