Targeting the resolution pathway of inflammation using Ac2–26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis
| العنوان: | Targeting the resolution pathway of inflammation using Ac2–26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis |
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| المؤلفون: | Donghao Fan, Qin Wang, Wenlang Liang, Xianyan Qin, Jiyu Fang, Liming He |
| المصدر: | Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 4, Pp 483-493 (2021) Asian Journal of Pharmaceutical Sciences |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmaceutical Science, Inflammation, 02 engineering and technology, RM1-950, Pharmacology, 010402 general chemistry, 01 natural sciences, Mediator, Ac2–26 peptide, Annexin, In vivo, medicine, Pegylated lipid nanoparticles, Rheumatoid arthritis, Autoimmune disease, business.industry, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, Bioavailability, Original Research Paper, Pro-resolving therapy, Drug delivery, Therapeutics. Pharmacology, medicine.symptom, 0210 nano-technology, business |
| الوصف: | Rheumatoid arthritis (RA) is a common autoimmune disease characterized by joint inflammation and immune dysfunction. Although various therapeutic approaches have been utilized for the treatment of RA in clinical applications, the low responsiveness of RA patients and undesired systemic toxicity are still unresolved problems. Targeting the resolution pathway of inflammation with pro-resolving mediators would evoke the protective actions of patient for combating the inflammation. Ac2–26, a 25-amino acid peptide derived from Annexin A (a pro-resolving mediator), has shown good efficacy in the treatment of inflammatory disorders. However, the low bioavailability of Ac2–26 peptides hinders their efficacy in vivo. In this paper, we formed PEGylated lipid nanoparticles (LDNPs) by the co-assembly of l-ascorbyl palmitate (L-AP) and N-(carbonyl methoxypolyethylene glycol-2000)-1,2-distearoyl-sn‑glycero-3-phosphoethanolamine (DSPE-PEG2k) to encapsulate and deliver Ac2–26 peptides to the arthritic rats. They showed good stability and biocompatibility. After being intravenously administrated, Ac2–26 peptide-loaded PEGylated lipid nanoparticles (ADNPs) showed the prolonged in vivo circulation time and enhanced accumulation in inflamed sites. In vivo therapeutic evaluations revealed that ADNPs could attenuate synovial inflammation and improve joint pathology. Therefore, the pro-resolving therapeutic strategy using ADNPs is effective in RA treatment. Graphical abstract The fabrication of ADNPs and their in vivo performances in arthritic rats.Image, graphical abstract |
| اللغة: | English |
| تدمد: | 1818-0876 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe325b68e1a41e77c3dd2e2373f3236Test http://www.sciencedirect.com/science/article/pii/S1818087621000295Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5fe325b68e1a41e77c3dd2e2373f3236 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18180876 |
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