Correlation between change in central subfield thickness and change in visual acuity in macular edema due to retinal vein occlusion: post hoc analysis of COPERNICUS, GALILEO, and VIBRANT
| العنوان: | Correlation between change in central subfield thickness and change in visual acuity in macular edema due to retinal vein occlusion: post hoc analysis of COPERNICUS, GALILEO, and VIBRANT |
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| المؤلفون: | Sophie Z, Gu, Onnisa, Nanegrungsunk, Susan B, Bressler, Weiming, Du, Fouad, Amer, Hadi, Moini, Neil M, Bressler |
| المصدر: | Graefe's Archive for Clinical and Experimental Ophthalmology. 260:3799-3807 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Clinical Trials as Topic, Cellular and Molecular Neuroscience, Ophthalmology, Treatment Outcome, Intravitreal Injections, Retinal Vein Occlusion, Visual Acuity, Humans, Angiogenesis Inhibitors, Macular Edema, Sensory Systems |
| الوصف: | Purpose Assess correlation between change in central subfield thickness (CST) and change in best-corrected visual acuity (BCVA) in eyes with macular edema due to retinal vein occlusion (RVO) that received intravitreal aflibercept injections (IAI). Methods Post hoc analysis of COPERNICUS and GALILEO trials for CRVO and VIBRANT trial for BRVO with relationships determined using Pearson correlation coefficient. Results In COPERNICUS, correlations (r) between change in CST and change in BCVA from baseline at weeks 12, 24, 52, and 100 were −0.36 (95% CI: −0.52, −0.18; P P P P P = 0.003). Similar findings were noted for GALILEO (r, −0.45 to −0.23) and VIBRANT (r, −0.36 to −0.32) trials. Conclusion In eyes treated with IAI for macular edema due to RVO, correlation between change in CST and change in BCVA was weak to moderate. While change in CST may be helpful in determining the need for anti-VEGF therapy, these findings do not support using changes in CST as a surrogate for changes in visual acuity outcomes. |
| تدمد: | 1435-702X 0721-832X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe2aa2258c6dd1254e3ee3cd11f8587Test https://doi.org/10.1007/s00417-022-05697-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5fe2aa2258c6dd1254e3ee3cd11f8587 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1435702X 0721832X |
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