Hyperinsulinaemic–hypoglycaemic glucose clamps in human research: a systematic review of the literature
| العنوان: | Hyperinsulinaemic–hypoglycaemic glucose clamps in human research: a systematic review of the literature |
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| المؤلفون: | Clementine E. M. Verhulst, Stephanie A. Amiel, Thomas R. Pieber, Rory J. McCrimmon, Therese W. Fabricius, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan, Mark L. Evans, Simon Heller, Peter Kristensen, Cees J. Tack |
| المساهمون: | Fabricius, Therese W. [0000-0002-6344-5408], Verhulst, Clementine E. M. [0000-0002-9905-7669], Kristensen, Peter L. [0000-0001-5431-824X], Tack, Cees J. [0000-0003-0322-1653], McCrimmon, Rory J. [0000-0002-3957-1981], Heller, Simon [0000-0002-2425-9565], Evans, Mark L. [0000-0001-8122-8987], Amiel, Stephanie A. [0000-0003-2686-5531], Pieber, Thomas R. [0000-0003-3554-0405], de Galan, Bastiaan E. [0000-0002-1255-7741], Pedersen-Bjergaard, Ulrik [0000-0003-0588-4880], Apollo - University of Cambridge Repository, Fabricius, Therese W [0000-0002-6344-5408], Verhulst, Clementine EM [0000-0002-9905-7669], Kristensen, Peter L [0000-0001-5431-824X], Tack, Cees J [0000-0003-0322-1653], McCrimmon, Rory J [0000-0002-3957-1981], Evans, Mark L [0000-0001-8122-8987], Amiel, Stephanie A [0000-0003-2686-5531], Pieber, Thomas R [0000-0003-3554-0405], de Galan, Bastiaan E [0000-0002-1255-7741] |
| المصدر: | Diabetologia Diabetologia, 64, 727-736 Diabetologia, 64, 4, pp. 727-736 on behalf of the Hypo-RESOLVE consortium 2021, ' Hyperinsulinaemic–hypoglycaemic glucose clamps in human research : a systematic review of the literature ', Diabetologia, vol. 64, pp. 727–736 . https://doi.org/10.1007/s00125-020-05361-8Test |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, Male, Biomedical Research, BLOOD, SYMPTOMS, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, subsequent hypoglycemia, hyperinsulinaemic-hypoglycaemic clamp, Type 2 diabetes, Diabetes mellitus, 0302 clinical medicine, systematic review, Medicine, 030212 general & internal medicine, Infusions, Intravenous, diabetes, Diabetes, Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6], Venous blood, Middle Aged, Glucose clamp technique, 3. Good health, Type 1 diabetes, Anesthesia, Female, Human, Adult, insulin, CAFFEINE, Adolescent, 030209 endocrinology & metabolism, UNAWARENESS, Article, Young Adult, equivalent hypoglycemia, 03 medical and health sciences, Predictive Value of Tests, Internal Medicine, Humans, Hypoglycemic Agents, GLUCAGON, counterregulatory response, human, Hyperinsulinaemic–hypoglycaemic clamp, business.industry, Insulin, Reproducibility of Results, medicine.disease, Hypoglycemia, Diabetes Mellitus, Type 1, Glucose, Clamp, Diabetes Mellitus, Type 2, Systematic review, Glucose Clamp Technique, Hypoglycaemia, business, Biomarkers, Blood sampling |
| الوصف: | Aims/hypothesis The hyperinsulinaemic–hypoglycaemic glucose clamp technique has been developed and applied to assess effects of and responses to hypoglycaemia under standardised conditions. However, the degree to which the methodology of clamp studies is standardised is unclear. This systematic review examines how hyperinsulinaemic–hypoglycaemic clamps have been performed and elucidates potential important differences. Methods A literature search in PubMed and EMBASE was conducted. Articles in English published between 1980 and 2018, involving adults with or without diabetes, were included. Results A total of 383 articles were included. There was considerable variation in essential methodology of the hypoglycaemic clamp procedures, including the insulin dose used (49-fold difference between the lowest and the highest rate), the number of hypoglycaemic steps (range 1−6), the hypoglycaemic nadirs (range 2.0–4.3 mmol/l) and the duration (ranging from 5 to 660 min). Twenty-seven per cent of the articles reported whole blood glucose levels, most venous levels. In 70.8% of the studies, a dorsal hand vein was used for blood sampling, with some form of hand warming to arterialise venous blood in 78.8% of these. Key information was missing in 61.9% of the articles. Conclusions/interpretation Although the hyperinsulinaemic–hypoglycaemic clamp procedure is considered the gold standard to study experimental hypoglycaemia, a uniform standard with key elements on how to perform these experiments is lacking. Methodological differences should be considered when comparing results between hypoglycaemic clamp studies. PROSPERO registration This systematic review is registered in PROSPERO (CRD42019120083). Graphical abstract |
| وصف الملف: | application/pdf; text/xml |
| تدمد: | 0012-186X |
| DOI: | 10.1007/s00125-020-05361-8 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f84b792c346cc641470bc9df699a98aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5f84b792c346cc641470bc9df699a98a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0012186X |
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| DOI: | 10.1007/s00125-020-05361-8 |