Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study
| العنوان: | Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study |
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| المؤلفون: | Cécile Delcourt, Catherine Helmer, Kalina Rajaobelina, C. Blanc-Bisson, Fritz-Line Vélayoudom-Céphise, Vincent Rigalleau, Laurence Blanco, Laure Alexandre, Kamel Mohammedi, Marie Monlun, Audrey Cougnard-Gregoire |
| المصدر: | Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-7 (2018) Cardiovascular Diabetology |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Glycation End Products, Advanced, Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Revascularization, 03 medical and health sciences, Skin autofluorescence, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, Macroangiopathy, Myocardial infarction, cardiovascular diseases, Advanced glycation end-products, Stroke, Original Investigation, Aged, Skin, Angiology, 2. Zero hunger, Type 1 diabetes, business.industry, Middle Aged, Prognosis, medicine.disease, 3. Good health, Diabetes Mellitus, Type 1, Cardiovascular Diseases, lcsh:RC666-701, Luminescent Measurements, Female, Cardiology and Cardiovascular Medicine, business, Body mass index, Biomarkers, Mace, Follow-Up Studies |
| الوصف: | Background Advanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searched for an association between SAF and major adverse cardiovascular events (MACE) incidence in subjects with Type 1 Diabetes (T1D) during a 7 year follow-up. Methods During year 2009, 232 subjects with T1D were included. SAF measurement, clinical [age, sex, body mass index (BMI), comorbidities] and biological data (HbA1C, blood lipids, renal parameters) were recorded. MACE (myocardial infarction, stroke, lower extremity amputation or a revascularization procedure) were registered at visits in the center or by phone call to general practitioners until 2016. Results The participants were mainly men (59.5%), 51.5 ± 16.7 years old, with BMI 25.0 ± 4.1 kg/m2, diabetes duration 21.5 ± 13.6 years, HbA1C 7.6 ± 1.1%. LDL cholesterol was 1.04 ± 0.29 g/L, estimated Glomerular Filtration Rates (CKD-EPI): 86.3 ± 26.6 ml/min/1.73 m2. Among these subjects, 25.1% were smokers, 45.3% had arterial hypertension, 15.9% had elevated AER (≥ 30 mg/24 h), and 9.9% subjects had a history of previous MACE. From 2009 to 2016, 22 patients had at least one new MACE: 6 myocardial infarctions, 1 lower limb amputation, 15 revascularization procedures. Their SAF was 2.63 ± 0.73 arbitrary units (AU) vs 2.08 ± 0.54 for other patients (p = 0.002). Using Cox-model, after adjustment for age (as the scale time), sex, diabetes duration, BMI, hypertension, smoking status, albumin excretion rates, statin treatment and a previous history of MACE, higher baseline levels of SAF were significantly associated with an increased risk of MACE during follow-up (HR = 4.13 [1.30–13.07]; p = 0.02 for 1 AU of SAF) and Kaplan–Meier curve follow-up showed significantly more frequent MACE in group with SAF upper the median (p = 0.001). Conclusion A high SAF predicts MACE in patients with T1D. Electronic supplementary material The online version of this article (10.1186/s12933-018-0718-8) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2c41cfbef7737659ed9004eaebbbbcTest http://link.springer.com/article/10.1186/s12933-018-0718-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5f2c41cfbef7737659ed9004eaebbbbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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