Genetic profiles to identify talents in elite endurance athletes and professional football players
| العنوان: | Genetic profiles to identify talents in elite endurance athletes and professional football players |
|---|---|
| المؤلفون: | David Varillas-Delgado, Esther Morencos, Jorge Gutiérrez-Hellín, Millán Aguilar-Navarro, Alejandro Muñoz, Nuria Mendoza Láiz, Teresa Perucho, Antonio Maestro, Juan José Tellería-Orriols |
| المساهمون: | Universidad Francisco de Vitoria |
| المصدر: | Scopus |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Multidisciplinary, Cytochrome P-450 CYP2D6, Athletes, Nucleotides, Iron, Football, Physical Endurance, Humans, Actinin, Genetic Profile |
| الوصف: | The genetic profile that is needed to identify talents has been studied extensively in recent years. The main objective of this investigation was to approach, for the first time, the study of genetic variants in several polygenic profiles and their role in elite endurance and professional football performance by comparing the allelic and genotypic frequencies to the non-athlete population. In this study, genotypic and allelic frequencies were determined in 452 subjects: 292 professional athletes (160 elite endurance athletes and 132 professional football players) and 160 non-athlete subjects. Genotyping of polymorphisms in liver metabolisers (CYP2D6, GSTM1, GSTP and GSTT), iron metabolism and energy efficiency (HFE, AMPD1 and PGC1a), cardiorespiratory fitness (ACE, NOS3, ADRA2A, ADRB2 and BDKRB2) and muscle injuries (ACE, ACTN3, AMPD1, CKM and MLCK) was performed by Polymerase Chain Reaction-Single Nucleotide Primer Extension (PCR-SNPE). The combination of the polymorphisms for the “optimal” polygenic profile was quantified using the genotype score (GS) and total genotype score (TGS). Statistical differences were found in the genetic distributions between professional athletes and the non-athlete population in liver metabolism, iron metabolism and energy efficiency, and muscle injuries (p This work was supported by grant from the Universidad Francisco de Vitoria (UFV) through the project “Genetic profile of elite and high-performance Caucasian athletes; comparison between endurance, power sports and non-athlete population” (UFV2020-18) (DV-D). |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef46c471db78d6e96b2b3d3933a9506Test http://hdl.handle.net/10651/66997Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ef46c471db78d6e96b2b3d3933a9506 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |