Impact of corneal cross‐linking on topical drug penetration in humans
| العنوان: | Impact of corneal cross‐linking on topical drug penetration in humans |
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| المؤلفون: | Christoph Tappeiner, Beatrice E. Frueh, Kaspar Schuerch, Markus Tschopp |
| المصدر: | Acta Ophthalmologica. 93 |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Keratoconus, Corneal penetration, Ultraviolet Rays, Administration, Topical, Corneal Stroma, Riboflavin, Muscarinic Agonists, Young Adult, Cornea, Humans, Medicine, Photosensitizing Agents, Topical drug, business.industry, Significant difference, Pilocarpine, Corneal Topography, Pupil, General Medicine, Penetration (firestop), medicine.disease, Ophthalmology, Cross-Linking Reagents, medicine.anatomical_structure, Photochemotherapy, Anesthesia, Female, Collagen, business, Pupillometry, medicine.drug |
| الوصف: | PURPOSE To analyse the influence of corneal cross-linking (CXL) with ultraviolet-A (UV-A) and riboflavin on drug permeability in human subjects. METHODS Keratoconus patients (n = 23; mean age 26.9 ± 5.8 years) undergoing a standard CXL procedure with UV-A (5.4 J/cm(2) , 30 min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3 min for 30 min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4 months after CXL. RESULTS Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before CXL and 4 months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4-month follow-up visit: mean decreases of 3.9 and 3.7 mm were observed 30 min after pilocarpine application, respectively (p > 0.05). CONCLUSIONS No significant influence of CXL on the corneal penetration of topically applied pilocarpine was observed in this clinical study. |
| تدمد: | 1755-3768 1755-375X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec05b32c47d3eb9b8bec1a78e286048Test https://doi.org/10.1111/aos.12595Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ec05b32c47d3eb9b8bec1a78e286048 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17553768 1755375X |
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