Association of NKG2A with treatment for chronic hepatitis C virus infection
| العنوان: | Association of NKG2A with treatment for chronic hepatitis C virus infection |
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| المؤلفون: | Salim I. Khakoo, R. J. Harrison, Anna Ettorre, Ann-Margaret Little |
| المصدر: | Clinical and Experimental Immunology. 161:306-314 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Time Factors, CD3 Complex, Translational Studies, T-Lymphocytes, Hepatitis C virus, Immunology, Cell Count, Interferon alpha-2, Biology, medicine.disease_cause, Antiviral Agents, Polyethylene Glycols, Natural killer cell, Interleukin 21, chemistry.chemical_compound, Immune system, Receptors, KIR, HLA Antigens, Interferon, Pegylated interferon, Ribavirin, medicine, Humans, Immunology and Allergy, Natural Cytotoxicity Triggering Receptor 3, Natural Cytotoxicity Triggering Receptor 1, Remission Induction, Interferon-alpha, Hepatitis C, Chronic, Middle Aged, Virology, CD56 Antigen, Recombinant Proteins, Killer Cells, Natural, medicine.anatomical_structure, chemistry, NK Cell Lectin-Like Receptor Subfamily K, Receptors, KIR2DL3, Receptors, KIR2DL1, Interleukin 12, RNA, Viral, Female, NK Cell Lectin-Like Receptor Subfamily C, medicine.drug |
| الوصف: | SummaryNatural killer (NK) cells are critical to the immune response to viral infections. Their functions are controlled by receptors for major histocompatibility complex (MHC) class I, including NKG2A and killer-cell immunoglobulin-like receptors (KIR). In order to evaluate the role of MHC class I receptors in the immune response to hepatitis C virus infection we have studied patients with chronic HCV infection by multi-parameter flow cytometry directly ex vivo. This has permitted evaluation of combinatorial expression of activating and inhibitory receptors on single NK cells. Individuals with chronic HCV infection had fewer CD56dim NK cells than healthy controls (4·9 ± 3·4% versus 9·0 ± 5·9%, P |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e959c0bff9424c95768ce121a7ac05aTest https://doi.org/10.1111/j.1365-2249.2010.04169.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e959c0bff9424c95768ce121a7ac05a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
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